Trial reportGynecologic oncology2012
Longitudinal evaluation of cancer-associated biomarkers before and after weight loss in RENEW study participants: implications for cancer risk reduction.
Trial report in Gynecologic oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intentional weight loss, weight cycling, and endometrial cancer risk: a systematic review and meta-analysis.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2019Pooled it
- Recommendations for high-priority research on cancer-related fatigue in children and adults.Journal of the National Cancer Institute · 2013Guideline
- Trial
- Inflammatory biomarker in adipose stem cells of women with endometrial cancer.Biomarkers in medicine · 2018Trial
- The use of novel technology-based weight loss interventions for obese women with endometrial hyperplasia and cancer.Gynecologic oncology · 2016Trial
- Review
- Increases in BMI contribute to worsening inflammatory biomarkers related to breast cancer risk in women: a longitudinal study.Breast cancer research and treatment · 2023Article
- The interplay of obesity, microbiome dynamics, and innovative anti-obesity strategies in the context of endometrial cancer progression and therapeutic approaches.Biochimica et biophysica acta. Reviews on cancer · 2023Review
- The Association Between Nutrition, Obesity, Inflammation, and Endometrial Cancer: A Scoping Review.Current nutrition reports · 2023Article
- Prevention of endometrial cancer through lifestyle Interventions: A systematic review and synthesis.Gynecologic oncology reports · 2022Review
- Article
- Role of adipocytokines in endometrial cancer progression.Frontiers in pharmacology · 2022Review
- The roles and clinical applications of interleukins in endometrial carcinoma.Frontiers in oncology · 2022Review
- Article
- Impact of bariatric surgery on cancer risk reduction.Annals of translational medicine · 2020Review
- The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk.International journal of cancer · 2019Article
- Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women.Endocrine · 2019Review
- Obesity: Risk factors, complications, and strategies for sustainable long-term weight management.Journal of the American Association of Nurse Practitioners · 2017Review
- Changes in inflammatory endometrial cancer risk biomarkers in individuals undergoing surgical weight loss.Gynecologic oncology · 2017Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
introductionObesity is a major risk factor for the development of endometrial cancer (EC). An improved understanding of biologic mechanisms associated with weight loss, including alteration in inflammation, hormonal balance, and cancer antigens expression may lead to the development of effective cancer prevention strategies. The goal of this study was to explore longitudinal biomarker changes in obese women who underwent weight loss intervention, testing the hypothesis biomarker levels can be altered through intentional weight loss.
methodsSerum samples from 89 participants with Class II and Class III obesity and 43 non morbidly obese comparisons were obtained in Re-Energize with Nutrition, Exercise and Weight Loss (RENEW) study as previously reported. Twenty-one bead-based xMAP immunoassays were utilized, including cancer-associated antigens, cytokines, chemokines, and hormones. One-way repeated measures ANOVA was used to examine the association between changes in biomarker expression levels over time (baseline, 6 months and 12 months). Linear mixed effects models were used to examine longitudinal relationships between biomarker expression levels.
resultsMean levels of VEGF, soluble E-selectin, GH, adiponectin, IL-6, IL-7, CA-125, and IGFBP-1 significantly differed between time periods. In adjusted mixed linear models, decreasing BMI was significantly associated with lower levels of soluble E-selectin and IL-6 and increases in GH, adiponectin, and IGFBP-1.
conclusionsThis is one of the first efforts to explore changes in cancer-associated biomarkers in a cohort of weight loss research participants at high risk for EC development. Our findings demonstrate that changes in the expression of markers can be achieved with weight loss intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.