ReviewMutation research
Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate.
Review in Mutation research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Association of exposure to phthalates with cardiometabolic risk factors in children and adolescents: a systematic review and meta-analysis.Environmental science and pollution research international · 2019Pooled it
- A systematic review on the adverse health effects of di-2-ethylhexyl phthalate.Environmental science and pollution research international · 2016Pooled it
- Reproductive and developmental effects of phthalate diesters in females.Critical reviews in toxicology · 2013Pooled it
- Phthalate exposure and lipid disruption in Taiwanese children: Insights from serum lipidomic approach.Journal of food and drug analysis · 2026Article
- Mechanism exploration of di(2-ethylhexyl) phthalate (DEHP)-induced hepatocellular carcinoma via network toxicology and molecular docking analysis.Discover oncology · 2026Article
- From Plastics to Prognosis:Diagnostics (Basel, Switzerland) · 2026Article
- The Function of PPARα in Cancer Drug Development: A Promising Target for Cancer Treatment.Current cancer drug targets · 2026Review
- Genetic evidence and multi-omics characterization of DEHP-relevant detoxification and metabolic heterogeneity in hepatocellular carcinoma.Frontiers in toxicology · 2026Article
- Toxicity and mechanistic analysis of di(2-ethylhexyl)phthalate in renal cell carcinoma progression: a systematic study with network toxicology and molecular docking strategies.Discover oncology · 2025Article
- Ameliorative Potential of Vitamin E and Selenium Against Di-2-Ethylhexyl Phthalate (DEHP)-Induced Toxicity in Adult Female Mice.Veterinary medicine international · 2025Article
- Confirmation of Di(2-ethylhexyl) phthalate-induced micronuclei by repeated dose liver micronucleus assay: focus on evaluation of liver micronucleus assay in young rats.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2024Article
- Impact of Plasticizer on the Intestinal Epithelial Integrity and Tissue-Repairing Ability within Cells in the Proximity of the Human Gut Microbiome.International journal of environmental research and public health · 2023Article
- Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk.Foods (Basel, Switzerland) · 2022Review
- Polysaccharide-Rich Fractions fromEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells.International journal of molecular sciences · 2020Article
- Article
- Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact.International journal of environmental research and public health · 2020Review
- Multiple Stressor Effects of Radon and Phthalates in Children: Background Information and Future Research.International journal of environmental research and public health · 2020Review
- Di-(2-ethylhexyl) Phthalate (DEHP) and Uterine Histological Characteristics.Development & reproduction · 2020Article
- Phthalate Exposure and Long-Term Epigenomic Consequences: A Review.Frontiers in genetics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Di(2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator agent that is widely used as a plasticizer to soften polyvinylchloride plastics and non-polymers. Both occupational (e.g., by inhalation during its manufacture and use as a plasticizer of polyvinylchloride) and environmental (medical devices, contamination of food, or intake from air, water and soil) routes of exposure to DEHP are of concern for human health. There is sufficient evidence for carcinogenicity of DEHP in the liver in both rats and mice; however, there is little epidemiological evidence on possible associations between exposure to DEHP and liver cancer in humans. Data are available to suggest that liver is not the only target tissue for DEHP-associated toxicity and carcinogenicity in both humans and rodents. The debate regarding human relevance of the findings in rats or mice has been informed by studies on the mechanisms of carcinogenesis of the peroxisome proliferator class of chemicals, including DEHP. Important additional mechanistic information became available in the past decade, including, but not limited to, sub-acute, sub-chronic and chronic studies with DEHP in peroxisome proliferator-activated receptor (PPAR) α-null mice, as well as experiments utilizing several transgenic mouse lines. Activation of PPARα and the subsequent downstream events mediated by this transcription factor represent an important mechanism of action for DEHP in rats and mice. However, additional data from animal models and studies in humans exposed to DEHP from the environment suggest that multiple molecular signals and pathways in several cell types in the liver, rather than a single molecular event, contribute to the cancer in rats and mice. In addition, the toxic and carcinogenic effects of DEHP are not limited to liver. The International Agency for Research on Cancer working group concluded that the human relevance of the molecular events leading to cancer elicited by DEHP in several target tissues (e.g., liver and testis) in rats and mice can not be ruled out and DEHP was classified as possibly carcinogenic to humans (Group 2B).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.