ReviewMolecular and cellular endocrinology2012
Consequences of RAS and MAPK activation in the ovary: the good, the bad and the ugly.
Review in Molecular and cellular endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- The Role of Gonadotropins and Growth Factor in Regulating Ras During Maturation in Cumulus-Oocyte Complexes of Pigs.Animals : an open access journal from MDPI · 2025Article
- Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice.npj aging · 2025Article
- Article
- Whole-exome sequencing and Drosophila modelling reveal mutated genes and pathways contributing to human ovarian failure.Reproductive biology and endocrinology : RB&E · 2024Article
- Transcriptomic Response of the Ovarian Follicle Complex in Post-Vitellogenic Rainbow Trout to 17α,20β-Dihdroxy-4-pregnen-3-one In Vitro.International journal of molecular sciences · 2024Article
- Cre-LoxP and tamoxifen-induced deletion of ovarian quiescin sulfhydryl oxidase 2 showed disruption of ovulatory activity in mice.Journal of ovarian research · 2024Article
- Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.BMC genomics · 2024Article
- Finishing the egg.Genetics · 2024Article
- Effects of prenatal and lactational exposure to iodoacetic acid on the F1 generation of mice†.Biology of reproduction · 2022Article
- MAPK Signaling Pathway Is Essential for Female Reproductive Regulation in the Cabbage Beetle,Cells · 2022Article
- Aberrant activation of KRAS in mouse theca-interstitial cells results in female infertility.Frontiers in physiology · 2022Article
- Effect of samul-tang on female fertility via RAS signaling pathway in ovaries of aged mice.Aging · 2021Article
- The Role of the Guanosine Nucleotide-Binding Protein in the Corpus Luteum.Animals : an open access journal from MDPI · 2021Review
- Article
- Genome-wide association analysis reveals the genetic locus for high reproduction trait in Chinese Arbas Cashmere goat.Genes & genomics · 2020Article
- Reporting on the Role of miRNAs and Affected Pathways on the Molecular Backbone of Ovarian Insufficiency: A Systematic Review and Critical Analysis Mapping of Future Research.Frontiers in cell and developmental biology · 2020Article
- Article
- A high-resolution X chromosome copy-number variation map in fertile females and women with primary ovarian insufficiency.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Differential gene expression analysis of human cumulus cells.Clinical and experimental reproductive medicine · 2019Article
- Identification of Novel MicroRNAs and Characterization of MicroRNA Expression Profiles in Zebrafish Ovarian Follicular Cells.Frontiers in endocrinology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This review summarizes studies providing evidence (1) that endogenous RAS activation regulates important physiological events during ovulation and luteinization (2) that expression of the mutant, active KRAS(G12D) in granulosa cells in vivo causes abnormal follicle growth arrest leading to premature ovarian failure and (3) that KRAS(G12D) expression in ovarian surface epithelial (OSE) cells renders them susceptible to the pathological outcome of transformation and tumor formation. These diverse effects of RAS highlight how critical its activation is linked to cell- and stage-specific events in the ovary that control normal processes and that can also lead to altered granulosa cell and OSE cell fates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.