ArticleNature neuroscience2011
Chromatin modification of Notch targets in olfactory receptor neuron diversification.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Identification of markers facilitating the study of support cells in adult olfactory sensilla in Drosophila.Insect biochemistry and molecular biology · 2026Article
- Prdm16 Amplifies Notch Signaling and Suppresses Venous Lineage Specification to Prevent Arteriovenous Malformations During Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Multilayer regulation underlies the functional precision and evolutionary potential of the olfactory system.Nature communications · 2025Article
- PRDM16, a new kid on the block in cardiovascular health and disease.Cardiovascular research · 2025Review
- Article
- An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system.EMBO reports · 2025Article
- An integrated anatomical, functional and evolutionary view of thebioRxiv : the preprint server for biology · 2025Article
- Review
- Integrated Patterning Programs DuringAnnual review of neuroscience · 2021Article
- Article
- Interplay Between Notch and YAP/TAZ Pathways in the Regulation of Cell Fate During Embryo Development.Frontiers in cell and developmental biology · 2021Review
- Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke.Frontiers in aging neuroscience · 2021Article
- Olfactory Receptor Gene Regulation in Insects: Multiple Mechanisms for Singular Expression.Frontiers in neuroscience · 2021Review
- Review
- Deletion of theInternational journal of molecular sciences · 2020Article
- Functional integration of "undead" neurons in the olfactory system.Science advances · 2020Article
- Evolution, developmental expression and function of odorant receptors in insects.The Journal of experimental biology · 2020Review
- Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system.Nature communications · 2019Article
- Strength in diversity: functional diversity among olfactory neurons of the same type.Journal of bioenergetics and biomembranes · 2019Review
- Recent Advances in Behavioral (Epi)Genetics in Eusocial Insects.Annual review of genetics · 2018Review
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9 authors.
Funding
Abstract
Neuronal-class diversification is central during neurogenesis. This requirement is exemplified in the olfactory system, which utilizes a large array of olfactory receptor neuron (ORN) classes. We discovered an epigenetic mechanism in which neuron diversity is maximized via locus-specific chromatin modifications that generate context-dependent responses from a single, generally used intracellular signal. Each ORN in Drosophila acquires one of three basic identities defined by the compound outcome of three iterated Notch signaling events during neurogenesis. Hamlet, the Drosophila Evi1 and Prdm16 proto-oncogene homolog, modifies cellular responses to these iteratively used Notch signals in a context-dependent manner, and controls odorant receptor gene choice and ORN axon targeting specificity. In nascent ORNs, Hamlet erases the Notch state inherited from the parental cell, enabling a modified response in a subsequent round of Notch signaling. Hamlet directs locus-specific modifications of histone methylation and histone density and controls accessibility of the DNA-binding protein Suppressor of Hairless at the Notch target promoter.
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Registered trials
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