ArticleNature neuroscience2011
Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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Who cites it
49 citing papers in PubMed.
- Control of associative learning by the mediodorsal thalamus-orbitofrontal cortex circuit.Nature communications · 2026Article
- Dissociable Thalamocortical Circuit Disruptions During Contextual Fear Renewal in PTSD.medRxiv : the preprint server for health sciences · 2026Article
- Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation.Molecular psychiatry · 2026Review
- The Timing of Attentional Distraction Matters in Facilitating Extinction of Trace Fear Memory.Experimental neurobiology · 2026Article
- Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons.Experimental physiology · 2026Article
- Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus.Glia · 2026Article
- Using in vivo MRI to reveal circuits that are sensitive to traumatic stress in male and female rats.Neuropharmacology · 2025Article
- A role for the thalamus in danger evoked awakening during sleep.Nature communications · 2025Article
- Article
- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- Role of Thalamic CaInternational journal of molecular sciences · 2025Article
- Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction.Molecular brain · 2025Article
- Neural Processing of Taste-Related Signals in the Mediodorsal Thalamus of Mice.bioRxiv : the preprint server for biology · 2025Article
- Beyond Pharmacology: A Narrative Review of Alternative Therapies for Anxiety Disorders.Diseases (Basel, Switzerland) · 2024Review
- Article
- Memory Trace for Fear Extinction: Fragile yet Reinforceable.Neuroscience bulletin · 2024Review
- Two contrasting mediodorsal thalamic circuits target the mouse medial prefrontal cortex.Journal of neurophysiology · 2024Article
- Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Functional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation.Nature communications · 2023Article
- The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice.Nature communications · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mediodorsal thalamic nucleus has been implicated in the control of memory processes. However, the underlying neural mechanism remains unclear. Here we provide evidence for bidirectional modulation of fear extinction by the mediodorsal thalamic nucleus. Mice with a knockout or mediodorsal thalamic nucleus-specific knockdown of phospholipase C β4 exhibited impaired fear extinction. Mutant mediodorsal thalamic nucleus neurons in slices showed enhanced burst firing accompanied by increased T-type Ca(2+) currents; blocking of T channels in vivo rescued the fear extinction. Tetrode recordings in freely moving mice revealed that, during extinction, the single-spike (tonic) frequency of mediodorsal thalamic nucleus neurons increased in wild-type mice, but was static in mutant mice. Furthermore, tonic-evoking microstimulations of the mediodorsal thalamic nucleus, contemporaneous with the extinction tones, rescued fear extinction in mutant mice and facilitated it in wild-type mice. In contrast, burst-evoking microstimulation suppressed extinction in wild-type mice, mimicking the mutation. These results suggest that the firing mode of the mediodorsal thalamic nucleus is critical for the modulation of fear extinction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.