Evidence map›Paper›PMID 22197728›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2012

Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications.

Justin F Galloway, Alan Winter, Kwan Hyi Lee, Jea Ho Park, Charlene M Dvoracek, Peter Devreotes, Peter C Searson

Abstract read
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Diagnosis of prostate cancer via nanotechnological approach.International journal of nanomedicine · 2015
    Review
  3. Article
  4. State-of-the-art in design rules for drug delivery platforms: lessons learned from FDA-approved nanomedicines.Journal of controlled release : official journal of the Controlled Release Society · 2014
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Justin F GallowayDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Alan Winter
Kwan Hyi Lee
Jea Ho Park
Charlene M Dvoracek
Peter Devreotes
Peter C Searson

Funding

ValidationU54CA151838 · NCI · JOHNS HOPKINS UNIVERSITY · PI POMPER, MARTIN G, SEARSON, PETER C · 2010 to 2014
$11.9M
SIGNAL TRANSDUCTION AND DICTYOSTELIUM DEVELOPMENTR01GM028007 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI DEVREOTES, PETER N · 1985 to 2004
$2.4M
NCI NIH HHS U54 CA151838NCI NIH HHS U54CA151838NIGMS NIH HHS R01 GM028007
6 · The paper itself

Abstract

The water solubilization of nanoparticles is key for many applications in biomedicine. Despite the importance of surface functionalization, progress has been largely empirical and very few systematic studies have been performed. Here we report on the water solubilization of quantum dots using lipid encapsulation. We systematically evaluate the monodispersity, zeta potential, stability, and quantum yield for quantum dots encapsulated with single and double acyl-chain lipids, pegylated double acyl-chain lipids, and single alkyl-chain surfactant molecules with charged head groups. We show that charged surfactants and pegylated lipids are important to obtain monodisperse suspensions with high yield and excellent long-term stability. FROM THE CLINICAL EDITOR: This study reports on solubilization of nanoparticles in water, a key, but often neglected aspect for biomedical applications. The authors demonstrate that charged surfactants and PEGylated lipids are important to obtain monodisperse suspensions with high yield and long-term stability.

Indexed as

Quantum DotsLipidsPolyethylene GlycolsSolubilitySurface-Active AgentsWaterLipidsPolyethylene GlycolsSurface-Active AgentsWater

Identifiers

PMID22197728
PMCPMC3320680

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.