ArticleSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy2012
Concentration profiles of collagen and proteoglycan in articular cartilage by Fourier transform infrared imaging and principal component regression.
Article in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Biomimetic Hydrogels for In Vitro Modelling of Nucleus Pulposus Degeneration: Effects of Extracellular Matrix Compositional Change on Physicochemical Properties and Cell Phenotype.Journal of functional biomaterials · 2025Article
- Protein Analysis by FT-IR/ATR Spectroscopy.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Infrared spectroscopy is suitable for objective assessment of articular cartilage health.Osteoarthritis and cartilage open · 2022Article
- Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage.Acta biomaterialia · 2021Article
- Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model.Biomedicines · 2021Article
- Fourier Transform Infrared Microspectroscopy Combined with Principal Component Analysis and Artificial Neural Networks for the Study of the Effect of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation on Articular Cartilage.International journal of molecular sciences · 2021Article
- Reversible electroadhesion of hydrogels to animal tissues for suture-less repair of cuts or tears.Nature communications · 2021Article
- An Application of Multivariate Data Analysis to Photoacoustic Imaging for the Spectral Unmixing of Gold Nanorods in Biological Tissues.Nanomaterials (Basel, Switzerland) · 2021Article
- Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage.Acta biomaterialia · 2019Article
- Osteoarthritis and intervertebral disc degeneration: Quite different, quite similar.JOR spine · 2018Review
- Imaging of Osteoarthritic Human Articular Cartilage using Fourier Transform Infrared Microspectroscopy Combined with Multivariate and Univariate Analysis.Scientific reports · 2016Article
- Comparative Study of Morphometric and Fourier Transform Infrared Spectroscopy Analyses of the Collagen Fibers in the Repair Process of Cutaneous Lesions.Advances in wound care · 2016Article
- Discrimination of healthy and osteoarthritic articular cartilage by Fourier transform infrared imaging and Fisher's discriminant analysis.Biomedical optics express · 2016Article
- Discrimination of healthy and osteoarthritic articular cartilages by Fourier transform infrared imaging and partial least squares-discriminant analysis.Journal of biomedical optics · 2015Article
- Proteoglycan concentrations in healthy and diseased articular cartilage by Fourier transform infrared imaging and principal component regression.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2014Article
- Structure-function relations and rigidity percolation in the shear properties of articular cartilage.Biophysical journal · 2014Article
- Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues.PloS one · 2013Article
- Correlation between bone marrow dose volumes and acute hematological toxicity in postoperative gynecological cancer patients.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Fourier-transform infrared imaging (FT-IRI) technique with the principal component regression (PCR) method was used to quantitatively determine the 2D images and the depth-dependent concentration profiles of two principal macromolecular components (collagen and proteoglycan) in articular cartilage. Ten 6 μm thick sections of canine humeral cartilage were imaged at a pixel size of 6.25 μm in FT-IRI. The infrared spectra extracted from FT-IRI experiments were imported into a PCR program to calculate the quantitative distributions of both collagen and proteoglycan in dry cartilage, which were subsequently converted into the wet-weight based concentration profiles. The proteoglycan profiles by FT-IRI and PCR significantly correlated in linear regression with the proteoglycan profiles by the non-destructive μMRI (the goodness-of-fit 0.96 and the Pearson coefficient 0.98). Based on these concentration relationships, the concentration images of collagen and proteoglycan in both healthy and lesioned articular cartilage were successfully constructed two dimensionally. The simultaneous construction of both collagen and proteoglycan concentration images demonstrates that this combined imaging and chemometrics approach could be used as a sensitive tool to accurately resolve and visualize the concentration distributions of macromolecules in biological tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.