Trial reportTransactions of the Royal Society of Tropical Medicine and Hygiene2012
Semi-recumbent body position fails to prevent healthcare-associated pneumonia in Vietnamese patients with severe tetanus.
Trial report in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02999815 (Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial
Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Effectiveness of Continuous Endotracheal Cuff Pressure Control for the Prevention of Ventilator-Associated Respiratory Infections: An Open-Label Randomized, Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Saudi Guideline for Mechanical Ventilation in Adults.Saudi journal of medicine & medical sciences · 2026Article
- Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update.Infection control and hospital epidemiology · 2022Article
- Body position for preventing ventilator-associated pneumonia for critically ill patients: a systematic review and network meta-analysis.Journal of intensive care · 2022Review
- The effects of tidal volume size and driving pressure levels on pulmonary complement activation: an observational study in critically ill patients.Intensive care medicine experimental · 2020Article
- Functional outcome and muscle wasting in adults with tetanus.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019Observational
- Clinical features and outcomes of tetanus: a retrospective study.Infection and drug resistance · 2019Article
- Intrathecal Immunoglobulin for treatment of adult patients with tetanus: A randomized controlled 2x2 factorial trial.Wellcome open research · 2018Article
- Ventilator-associated respiratory infection in a resource-restricted setting: impact and etiology.Journal of intensive care · 2017Article
- Prevention of hospital-acquired pneumonia in non-ventilated adult patients: a narrative review.Antimicrobial resistance and infection control · 2016Review
- Ventilatory support of patients with sepsis or septic shock in resource-limited settings.Intensive care medicine · 2016Article
- Prognosis of neonatal tetanus in the modern management era: an observational study in 107 Vietnamese infants.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2015Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Healthcare-associated pneumonia (HCAP) is a common complication in patients with severe tetanus. Nursing tetanus patients in a semi-recumbent body position could reduce the incidence of HCAP. In a randomised controlled trial we compared the occurrence of HCAP in patients with severe tetanus nursed in a semi-recumbent (30°) or supine position. A total of 229 adults and children (aged ≥1 year) with severe tetanus admitted to hospital in Vietnam, were randomly assigned to a supine (n=112) or semi-recumbent (n=117) position. For patients maintaining their assigned positions and in hospital for>48h there was no significant difference between the two groups in the frequency of clinically suspected pneumonia [22/106 (20.8%) vs 26/104 (25.0%); p=0.464], pneumonia rate/1000 intensive care unit days (13.9 vs 14.6; p=0.48) and pneumonia rate/1000 ventilated days (39.2 vs 38.1; p=0.72). Mortality in the supine patients was 11/112 (9.8%) compared with 17/117 (14.5%) in the semi-recumbent patients (p=0.277). The overall complication rate [57/112 (50.9%) vs 76/117 (65.0%); p=0.03] and need for tracheostomy [51/112 (45.5%) vs 69/117 (58.9%); p=0.04) was greater in semi-recumbent patients. Semi-recumbent body positioning did not prevent the occurrence of HCAP in severe tetanus patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.