ReviewCurrent opinion in cell biology2012
The structure of cell-matrix adhesions: the new frontier.
Review in Current opinion in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- The role and regulation of integrins in cell migration and invasion.Nature reviews. Molecular cell biology · 2025Review
- Preparing samples from whole cells using focused-ion-beam milling for cryo-electron tomography.Nature protocols · 2020Article
- Leptospirosis is an invasive infectious and systemic inflammatory disease.Biomedical journal · 2020Review
- Hierarchical Micro-Nano Topography Promotes Cell Adhesion and Osteogenic Differentiation via Integrin α2-PI3K-AKT Signaling Axis.Frontiers in bioengineering and biotechnology · 2020Article
- Standard Loading Profile in Matrix Rigidity Sensing.Biophysical journal · 2018Article
- Mechanoepigenetics.Frontiers in cell and developmental biology · 2016Article
- A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration.Nature communications · 2015Article
- Accurate membrane tracing in three-dimensional reconstructions from electron cryotomography data.Ultramicroscopy · 2015Article
- Flightless I interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling.Molecular biology of the cell · 2015Article
- Prometastatic NEDD9 Regulates Individual Cell Migration via Caveolin-1-Dependent Trafficking of Integrins.Molecular cancer research : MCR · 2015Article
- Automated analysis of cell-matrix adhesions in 2D and 3D environments.Scientific reports · 2015Article
- β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer.Frontiers in pharmacology · 2015Review
- On a poroviscoelastic model for cell crawling.Journal of mathematical biology · 2015Article
- Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling.PloS one · 2015Article
- A material-based platform to modulate fibronectin activity and focal adhesion assembly.BioResearch open access · 2014Article
- Structural links between the renal stem/progenitor cell niche and the organ capsule.Histochemistry and cell biology · 2014Article
- The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover.FEBS letters · 2013Article
- Mechanosensitivity and compositional dynamics of cell-matrix adhesions.EMBO reports · 2013Review
- Two modes of integrin activation form a binary molecular switch in adhesion maturation.Molecular biology of the cell · 2013Article
- Remodeling of calcium signaling in tumor progression.Journal of biomedical science · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Adhesions between the cell and the extracellular matrix (ECM) are mechanosensitive multi-protein assemblies that transmit force across the cell membrane and regulate biochemical signals in response to the chemical and mechanical environment. These combined functions in force transduction, signaling and mechanosensing contribute to cellular phenotypes that span development, homeostasis and disease. These adhesions form, mature and disassemble in response to actin organization and physical forces that originate from endogenous myosin activity or external forces by the extracellular matrix. Despite advances in our understanding of the protein composition, interactions and regulation, our understanding of matrix adhesion structure and organization, how forces affect this organization, and how these changes dictate specific signaling events is limited. Insights across multiple structural levels are acutely needed to elucidate adhesion structure and ultimately the molecular basis of signaling and mechanotransduction. Here we describe the challenges and recent advances and prospects for unraveling the structure of cell-matrix adhesions and their response to force.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.