Evidence map›Paper›PMID 22196786›Full record

ArticleThe American journal of cardiology2012

Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease.

Alexander Lowenthal, Benjamin Villareal Camacho, Shiri Lowenthal, Luz Natal-Hernandez, Walter Liszewski, Nancy K Hills, Jeffrey R Fineman, Harold S Bernstein

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00571233 (Identification of Biomarkers for Heart Failure in Children With Single Ventricle Physiology), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00571233 completednot on this map

Identification of Biomarkers for Heart Failure in Children With Single Ventricle Physiology

TypeobservationalSponsorUniversity of California, San FranciscoRan2007 to 2015Enrolled71ConditionsTricuspid Atresia, Hypoplastic Left Heart Syndrome, Unbalanced AV Canal
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
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  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Cardiac biomarkers in children with congenital heart disease.World journal of pediatrics : WJP · 2015
    Review
  14. Article
  15. Review
  16. Gene expression and β-adrenergic signaling are altered in hypoplastic left heart syndrome.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2014
    Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander LowenthalDepartment of Pediatrics, University of California, San Francisco, California, USA.
Benjamin Villareal Camacho
Shiri Lowenthal
Luz Natal-Hernandez
Walter Liszewski
Nancy K Hills
Jeffrey R Fineman
Harold S Bernstein
University of California, San Francisco · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL RR024131
6 · The paper itself

Abstract

Children with single ventricle (SV) physiology have increased ventricular work and are at risk of heart failure (HF). However, a HF diagnosis is especially difficult, because few objective measures of HF have been validated in this cohort. We have previously shown that plasma B-type natriuretic peptide (BNP) levels are sensitive and specific for detecting HF in a small, heterogeneous SV cohort. The aim of the present study was to define the effect of SV morphology and stage of palliation on the correlation between BNP and HF. We also examined the utility of N-terminal pro-BNP (NT-proBNP), a more stable product of pre-BNP processing, as a biomarker of HF in these patients. A cross-sectional observational study of SV children aged 1 month to 7 years was conducted. The presence of HF was defined as a Ross score > 2. The association of BNP or NT-proBNP with HF was assessed using logistic regression analysis and receiver operating characteristic curves. Of the 71 included children, 22 (31%) had clinical HF. A doubling of BNP was associated with an odds ratio for HF of 2.20 (95% confidence interval 1.36 to 3.55, p = 0.001) with a c-statistic > 75%, yielding a detection threshold of ≥ 45 pg/ml. This threshold was preserved when patients were stratified by the right ventricular morphology or stage of surgical palliation. Similarly, a doubling of NT-proBNP was associated with an odds ratio for HF of 1.92 (95% confidence interval 1.17 to 3.14, p = 0.009). In contrast to BNP, the threshold value of NT-proBNP for predicting HF decreased with the stage of palliation. In conclusion, plasma BNP and NT-proBNP are reliable tests for clinical HF in young children with SV physiology, specifically those with right ventricular morphology, regardless of the stage of palliation.

Indexed as

BiomarkersCardiac CatheterizationChildChild, PreschoolCross-Sectional StudiesFemaleFollow-Up StudiesHeart Defects, CongenitalHeart FailureHeart VentriclesHumansInfantInfant, NewbornMaleNatriuretic Peptide, BrainPeptide FragmentsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Protein Precursors

Identifiers

PMID22196786
PMCPMC3294194
OpenAlexW2079291178

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.