ArticleCell2011
Adaptation to P element transposon invasion in Drosophila melanogaster.
Article in Cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
144 citing papers in PubMed, 267 citations in OpenAlex.
- The impact of P-element-induced hybrid dysgenesis on the male germline in Drosophila simulans.Genetics · 2026Article
- Host-transposable element coexistence: a matter of resistance, tolerance and trade-off.The EMBO journal · 2026Review
- Article
- Reproductive phasiRNAs are the piRNAs of plants.Trends in genetics : TIG · 2026Review
- Chromatin unfolding via loops can drive clustered transposon insertion.Biophysical journal · 2025Article
- The impact of insertion bias into piRNA clusters on the invasion of transposable elements.BMC biology · 2025Article
- Rapid emergence of non-autonomous elements may stop P-element invasions in the absence of a piRNA-based host defence.PLoS genetics · 2025Article
- Article
- Article
- Calcium Homeostasis Is Involved in the Modulation of Gene Expression by MSL2 in Imbalanced Genomes.Cells · 2024Article
- piRNA Defense Against Endogenous Retroviruses.Viruses · 2024Review
- Tolerance thresholds underlie responses to DNA damage during germline development.Genes & development · 2024Article
- Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing.Nature structural & molecular biology · 2024Article
- Rapid evolution of piRNA clusters in theGenome research · 2024Article
- Review
- Experimentally evolvingGenome research · 2024Article
- Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes.Genome biology · 2024Article
- Structural Variants and Speciation: Multiple Processes at Play.Cold Spring Harbor perspectives in biology · 2024Review
- Embryonic piRNAs target horizontally transferred vertebrate transposons in assassin bugs.Frontiers in cell and developmental biology · 2024Article
- Maternally inherited siRNAs initiate piRNA cluster formation.Molecular cell · 2023Article
84 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway adapts to invasion of new transposons. In Drosophila, piRNAs are encoded by heterochromatic clusters and maternally deposited in the embryo. Paternally inherited P element transposons thus escape silencing and trigger a hybrid sterility syndrome termed P-M hybrid dysgenesis. We show that P-M hybrid dysgenesis activates both P elements and resident transposons and disrupts the piRNA biogenesis machinery. As dysgenic hybrids age, however, fertility is restored, P elements are silenced, and P element piRNAs are produced de novo. In addition, the piRNA biogenesis machinery assembles, and resident elements are silenced. Significantly, resident transposons insert into piRNA clusters, and these new insertions are transmitted to progeny, produce novel piRNAs, and are associated with reduced transposition. P element invasion thus triggers heritable changes in genome structure that appear to enhance transposon silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.