Evidence map›Paper›PMID 22196722›Full record

ArticleCell2011

Learning to protect your genome on the fly.

Mia T Levine, Harmit S Malik

Abstract readComment
In one paragraph

Article in Cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Mia T LevineBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Harmit S Malik

Funding

Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
Phylogenomics and functional diversification of the Heterochromatin Protein 1 genF32GM097897 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LEVINE, MIA TAUNA · 2011 to 2012
$105k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM097897NIGMS NIH HHS F32GM097897NIGMS NIH HHS R01 GM074108NIGMS NIH HHS R01GM074108
6 · The paper itself

Abstract

Piwi-interacting RNAs (piRNAs) help defend host genomes against germline transposons. In this issue of Cell, Khurana et al. show how alterations in the piRNA-encoding loci within a single generation allow a naive fly genome to overcome the initially insurmountable challenge imposed by a newly encountered mobile element.

Identifiers

PMID22196722
PMCPMC3725141

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.