ArticleDrug and alcohol dependence2012
Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons.
Article in Drug and alcohol dependence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Dopamine internalization via UptakeFrontiers in pharmacology · 2024Article
- The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray.Molecular pharmacology · 2015Article
- Endocannabinoid signalling and the deteriorating brain.Nature reviews. Neuroscience · 2015Review
- Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons.Journal of neurochemistry · 2012Article
- Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception.The journal of pain · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBuprenorphine is an opioid receptor ligand whose mechanism of action is incompletely understood.
methodsUsing Ca(2+) imaging, we assessed the effects of buprenorphine, β-endorphin, and morphine on cytosolic Ca(2+) concentration [Ca(2+)](i), in rat striatal neurons.
resultsBuprenorphine (0.01-1 μM) increased [Ca(2+)](i) in a dose-dependent manner in a subpopulation of rat striatal neurons. The effect of buprenorphine was largely reduced by naloxone, a non-selective opioid receptor antagonist, but not by μ, κ, δ or NOP-selective antagonists. β-Endorphin (0.1 μM) increased [Ca(2+)](i) with a lower amplitude and slower time course than buprenorphine. Similar to buprenorphine, the effect of β-endorphin was markedly decreased by naloxone, but not by opioid-selective antagonists. Morphine (0.1-10 μM), did not affect [Ca(2+)](i) in striatal neurons.
conclusionsOur results suggest that buprenorphine and β-endorphin act on a distinct type/subtype of plasmalemmal opioid receptors or activate intracellular opioid-like receptor(s) in rat striatal neurons.
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Registered trials
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