ReviewRedox report : communications in free radical research2011
Caloric restriction and redox state: does this diet increase or decrease oxidant production?
Review in Redox report : communications in free radical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.Nutrition reviews · 2021Trial
- Sulfur amino acid restriction and caloric restriction induce divergent redox metabolism-related adaptations in male F344 rats.Redox report : communications in free radical research · 2026Article
- Dietary energy restriction in neurological diseases: what's new?European journal of nutrition · 2023Review
- Protein Kinase CK2 Is Upregulated by Calorie Restriction and Induces Autophagy.Molecules and cells · 2022Article
- Machine learning-based predictions of dietary restriction associations across ageing-related genes.BMC bioinformatics · 2022Article
- The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease.Antioxidants (Basel, Switzerland) · 2021Review
- Mitochondria Matter: Systemic Aspects of Nonalcoholic Fatty Liver Disease (NAFLD) and Diagnostic Assessment of Liver Function by Stable Isotope Dynamic Breath Tests.International journal of molecular sciences · 2021Review
- Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?International journal of molecular sciences · 2021Review
- Protocols for Mitochondria as the Target of Pharmacological Therapy in the Context of Nonalcoholic Fatty Liver Disease (NAFLD).Methods in molecular biology (Clifton, N.J.) · 2021Review
- Precompetitional Weight Reduction Modifies Prooxidative-Antioxidative Status in Judokas.Oxidative medicine and cellular longevity · 2019Article
- Intermittent Fasting: Is the Wait Worth the Weight?Current obesity reports · 2018Review
- Comparison of a Restricted and Unrestricted Vegan Diet Plan with a Restricted Omnivorous Diet Plan on Health-Specific Measures.Healthcare (Basel, Switzerland) · 2015Article
- Intermittent fasting results in tissue-specific changes in bioenergetics and redox state.PloS one · 2015Article
- Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice.Aging cell · 2014Article
- Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast.Experimental gerontology · 2013Article
- Effects of dietary nutrients on volatile breath metabolites.Journal of nutritional science · 2013Article
- The reliability of clinical dynamic monitoring of redox status using a new redox potential (ORP) determination method.Redox report : communications in free radical research · 2013Article
- Reduced High-Dose Radiation-Induced Residual Genotoxic Damage by Induction of Radioadaptive Response and Prophylactic Mild Dietary Restriction in Mice.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calorie restriction (CR) is well established to enhance the lifespan of a wide variety of organisms, although the mechanisms are still being uncovered. Recently, some authors have suggested that CR acts through hormesis, enhancing the production of reactive oxygen species (ROS), activating stress response pathways, and increasing lifespan. Here, we review the literature on the effects of CR and redox state. We find that there is no evidence in rodent models of CR that an increase in ROS production occurs. Furthermore, results in Caenorhabditis elegans and Saccharomyces cerevisiae suggesting that CR increases intracellular ROS are questionable, and probably cannot be resolved until adequate, artifact free, tools for real-time, quantitative, and selective measurements of intracellular ROS are developed. Overall, the largest body of work indicates that CR improves redox state, although it seems improbable that a global improvement in redox state is the mechanism through which CR enhances lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.