Evidence map›Paper›PMID 22195775›Full record

ReviewCurrent opinion in genetics & development2012

Genomic imprinting: recognition and marking of imprinted loci.

Lara K Abramowitz, Marisa S Bartolomei

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 113 citations in OpenAlex.

  1. Article
  2. Article
  3. lncRNA HOTAIR and Cardiovascular diseases.Functional & integrative genomics · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Imprinted Genes and Multiple Sclerosis: What Do We Know?International journal of molecular sciences · 2021
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Born to Cry: A Genetic Dissection of Infant Vocalization.Frontiers in behavioral neuroscience · 2018
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lara K AbramowitzDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Marisa S Bartolomei
University of Pennsylvania · US

Funding

Research Project 4: Epigenetic Regulation of Retrotransposon Silencing and Male Fertility in the MouseP50HD068157 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Suneeta Senapati · 2014 to 2026
$16.3M
SEQUENCES CONTROLLING H19 GENE IMPRINTINGR01GM051279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1994 to 2024
$5.1M
PROJECT 4: TARGETING ADP-RIBOSE POLYMER DEPENDENT EPIGENETIC EVENTS IN MALE LINEU54HD068157 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI COUTIFARIS, CHRISTOS · 2011 to 2013
$4.8M
Sequences controlling H19 Gene ImprintingR37GM051279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 2011 to 2020
$3.9M
Epigenetic Regulation of Imprinting in Mouse EmbryoR01HD042026 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 2002 to 2012
$3.5M
NICHD NIH HHS HD042026NICHD NIH HHS HD068157NICHD NIH HHS P50 HD068157NICHD NIH HHS R01 HD042026NICHD NIH HHS U54 HD068157NIGMS NIH HHS GM051279NIGMS NIH HHS R01 GM051279NIGMS NIH HHS R37 GM051279
6 · The paper itself

Abstract

Genomic imprinting is an epigenetic process resulting in the monoallelic parent-of-origin-specific expression of a subset of genes in the mammalian genome. The parental alleles are differentially marked by DNA methylation during gametogenesis when the genomes are in separate compartments. How methylation machinery recognizes and differentially modifies these imprinted regions in germ cells remains a key question in the field. While studies have focused on determining a sequence signature that alone could distinguish imprinted regions from the rest of the genome, recent reports do not support such a hypothesis. Rather, it is becoming clear that features such as transcription, histone modifications and higher order chromatin are employed either individually or in combination to set up parental imprints.

Indexed as

Genomic ImprintingAnimalsDNA MethylationGenetic LociHistonesHumansTranscription, GeneticHistones

Identifiers

PMID22195775
PMCPMC3314145
OpenAlexW2154476663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.