Evidence map›Paper›PMID 22195134›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2011

Determining the reasons for medication prescriptions in the EHR using knowledge and natural language processing.

Ying Li, Hojjat Salmasian, Rave Harpaz, Herbert Chase, Carol Friedman

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Medication-indication knowledge bases: a systematic review and critical appraisal.Journal of the American Medical Informatics Association : JAMIA · 2015
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Hierarchical Concept Relations Improve Detection of Off-Label Drug Use in Electronic Health Records Data.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2023
    Article
  8. Review
  9. Article
  10. Developing a Data-driven Medication Indication Knowledge Base using a Large Scale Medical Claims Database.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Generalized Extraction and Classification of Span-Level Clinical Phrases.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2018
    Article
  15. Article
  16. Article
  17. Article
  18. Standardizing adverse drug event reporting data.Journal of biomedical semantics · 2014
    Article
  19. Analysis of medication and indication occurrences in clinical notes.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2014
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ying LiDepartment of Biomedical Informatics, Columbia University, New York, NY, USA.
Hojjat Salmasian
Rave Harpaz
Herbert Chase
Carol Friedman

Funding

Training in Biomedical Informatics at Columbia UniversityT15LM007079 · NLM · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI NOEMIE ELHADAD, GEORGE M HRIPCSAK · 1992 to 2026
$28.9M
Pharmacovigilence using Natural Language Processing, Statistics, and the EHRR01LM010016 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FRIEDMAN, CAROL · 2009 to 2016
$3.4M
NLM NIH HHS 1R01LM010016NLM NIH HHS 3R01LM010016-01S1NLM NIH HHS 3R01LM010016-02S1NLM NIH HHS 5T15-LM0070-19NLM NIH HHS R01 LM010016NLM NIH HHS T15 LM007079
6 · The paper itself

Abstract

Knowledge of medication indications is significant for automatic applications aimed at improving patient safety, such as computerized physician order entry and clinical decision support systems. The Electronic Health Record (EHR) contains pertinent information related to patient safety such as information related to appropriate prescribing. However, the reasons for medication prescriptions are usually not explicitly documented in the patient record. This paper describes a method that determines the reasons for medication uses based on information occurring in outpatient notes. The method utilizes drug-indication knowledge that we acquired, and natural language processing. Evaluation showed the method obtained a sensitivity of 62.8%, specificity of 93.9%, precision of 90% and F-measure of 73.9%. This pilot study demonstrated that linking external drug indication knowledge to the EHR for determining the reasons for medication use was promising, but also revealed some challenges. Future work will focus on increasing the accuracy and coverage of the indication knowledge and evaluating its performance using a much larger set of drugs frequently used in the outpatient population.

Indexed as

Artificial IntelligenceDrug PrescriptionsElectronic Health RecordsNatural Language ProcessingPractice Patterns, Physicians'HumansKnowledge BasesPatient SafetyPilot Projects

Identifiers

PMID22195134
PMCPMC3243251

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.