ArticlePloS one2011
Disorder predictors also predict backbone dynamics for a family of disordered proteins.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Modernizing biomolecular NMR: The POKY suite.The Journal of biological chemistry · 2026Review
- Conformational Analyses of the AHD1-UBAN Region of TNIP1 Highlight Key Amino Acids for Interaction with Ubiquitin.Biomolecules · 2025Article
- Asymmetric dynamic coupling promotes alternative evolutionary pathways in an enzyme dimer.Scientific reports · 2020Article
- Predictions of Backbone Dynamics in Intrinsically Disordered Proteins Using De Novo Fragment-Based Protein Structure Predictions.Scientific reports · 2017Article
- Prediction of Spontaneous Protein Deamidation from Sequence-Derived Secondary Structure and Intrinsic Disorder.PloS one · 2015Article
- Classification of intrinsically disordered regions and proteins.Chemical reviews · 2014Review
- The DynaMine webserver: predicting protein dynamics from sequence.Nucleic acids research · 2014Article
- Origins of Myc proteins--using intrinsic protein disorder to trace distant relatives.PloS one · 2013Article
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3 authors.
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Abstract
Several algorithms have been developed that use amino acid sequences to predict whether or not a protein or a region of a protein is disordered. These algorithms make accurate predictions for disordered regions that are 30 amino acids or longer, but it is unclear whether the predictions can be directly related to the backbone dynamics of individual amino acid residues. The nuclear Overhauser effect between the amide nitrogen and hydrogen (NHNOE) provides an unambiguous measure of backbone dynamics at single residue resolution and is an excellent tool for characterizing the dynamic behavior of disordered proteins. In this report, we show that the NHNOE values for several members of a family of disordered proteins are highly correlated with the output from three popular algorithms used to predict disordered regions from amino acid sequence. This is the first test between an experimental measure of residue specific backbone dynamics and disorder predictions. The results suggest that some disorder predictors can accurately estimate the backbone dynamics of individual amino acids in a long disordered region.
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