ArticlePloS one2011
Protein profile changes during porcine oocyte aging and effects of caffeine on protein expression patterns.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effect of the time interval between oocyte retrieval and ICSI on embryo development and reproductive outcomes: a systematic review.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Examining the impact of denudation and ICSI timing on embryological and clinical outcomes in oocyte donation cycles.Journal of assisted reproduction and genetics · 2026Article
- In Silico, In Vitro, and In Vivo Evaluation of Caffeine-Coated Nanoparticles as a Promising Therapeutic Avenue for AML through NF-Kappa B and TRAIL Pathways Modulation.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Proteomic analysis implicates that postovulatory aging leads to aberrant gene expression, biosynthesis, RNA metabolism and cell cycle in mouse oocytes.Journal of ovarian research · 2022Article
- Histone Acetylation Dynamics during In Vivo and In Vitro Oocyte Aging in Common CarpInternational journal of molecular sciences · 2021Article
- The Molecular Regulation in the Pathophysiology in Ovarian Aging.Aging and disease · 2021Review
- Asiatic acid protects oocytes againstAging · 2020Article
- Inhibitory effects of astaxanthin on postovulatory porcine oocyte aging in vitro.Scientific reports · 2020Article
- Performing ICSI within 4 hours after denudation optimizes clinical outcomes in ICSI cycles.Reproductive biology and endocrinology : RB&E · 2020Article
- Improved preimplantation development of porcine somatic cell nuclear transfer embryos by caffeine treatment.Journal of veterinary science · 2019Article
- Advances inInternational journal of veterinary science and medicine · 2018Review
- Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonic development in the pig.Aging · 2017Article
- Expression profiles and function analysis of microRNAs in postovulatory aging mouse oocytes.Aging · 2017Article
- Inhibitory mechanism of peptides with a repeating hydrophobic and hydrophilic residue pattern on interleukin-10.Human vaccines & immunotherapeutics · 2017Article
- Article
- Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.Human reproduction (Oxford, England) · 2016Article
- Hydrogen sulfide donor protects porcine oocytes against aging and improves the developmental potential of aged porcine oocytes.PloS one · 2015Article
- Discovery of porcine maternal factors related to nuclear reprogramming and early embryo development by proteomic analysis.Proteome science · 2015Article
- Identification and characterization of an oocyte factor required for porcine nuclear reprogramming.The Journal of biological chemistry · 2014Article
- Oxidative stress in aging: advances in proteomic approaches.Oxidative medicine and cellular longevity · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been shown that oocyte aging critically affects reproduction and development. By using proteomic tools, in the present study, changes in protein profiles during porcine oocyte aging and effects of caffeine on oocyte aging were investigated. By comparing control MII oocytes with aging MII oocytes, we identified 23 proteins that were up-regulated and 3 proteins that were down-regulated during the aging process. In caffeine-treated oocytes, 6 proteins were identified as up-regulated and 12 proteins were identified as down-regulated. A total of 38 differentially expressed proteins grouped into 5 regulation patterns were determined to relate to the aging and anti-aging process. By using the Gene Ontology system, we found that numerous functional gene products involved in metabolism, stress response, reactive oxygen species and cell cycle regulation were differentially expressed during the oocyte aging process, and most of these proteins are for the first time reported in our study, including 2 novel proteins. In addition, several proteins were found to be modified during oocyte aging. These data contribute new information that may be useful for future research on cellular aging and for improvement of oocyte quality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.