ArticlePloS one2011
Prediction of antibacterial activity from physicochemical properties of antimicrobial peptides.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Exploration of Novel Antimicrobial Peptides from Gut Probiotics Enterococcus spp. Against Extensively drug-resistant Pathogens Through cutting-edge Computational Discovery.Probiotics and antimicrobial proteins · 2026Article
- Lipid Shape as a Membrane Activity Modulator of a Fusogenic Antimicrobial Peptide.Journal of chemical information and modeling · 2025Article
- De Novo Antimicrobial Peptide Design with Feedback Generative Adversarial Networks.International journal of molecular sciences · 2024Article
- A Simulation Model for the Non-Electrogenic Uniport Carrier-Assisted Transport of Ions across Lipid Membranes.Membranes · 2022Article
- Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes.Frontiers in cell and developmental biology · 2022Review
- Anticancer peptide Q7 suppresses the growth and migration of human endometrial cancer by inhibiting DHCR24 expression and modulating the AKT-mediated pathway.International journal of medical sciences · 2022Article
- Preliminary Characterization of NP339, a Novel Polyarginine Peptide with Broad Antifungal Activity.Antimicrobial agents and chemotherapy · 2021Article
- Modeling Cell Selectivity of Antimicrobial Peptides: How Is the Selectivity Influenced by Intracellular Peptide Uptake and Cell Density.Frontiers in medical technology · 2021Article
- Amino Acid Reduction Can Help to Improve the Identification of Antimicrobial Peptides and Their Functional Activities.Frontiers in genetics · 2021Article
- The Cytotoxicity of RNase-Derived Peptides.Biomolecules · 2020Article
- De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Article
- Unraveling the bioactivity of anticancer peptides as deduced from machine learning.EXCLI journal · 2018Review
- Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance.Scientific reports · 2017Article
- Peptides with Dual Antimicrobial and Anticancer Activities.Frontiers in chemistry · 2017Review
- ProInflam: a webserver for the prediction of proinflammatory antigenicity of peptides and proteins.Journal of translational medicine · 2016Article
- Real-time measurement of membrane conformational states induced by antimicrobial peptides: balance between recovery and lysis.Scientific reports · 2014Article
- Synthetic biology outside the cell: linking computational tools to cell-free systems.Frontiers in bioengineering and biotechnology · 2014Review
- Activity determinants of helical antimicrobial peptides: a large-scale computational study.PloS one · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Consensus is gathering that antimicrobial peptides that exert their antibacterial action at the membrane level must reach a local concentration threshold to become active. Studies of peptide interaction with model membranes do identify such disruptive thresholds but demonstrations of the possible correlation of these with the in vivo onset of activity have only recently been proposed. In addition, such thresholds observed in model membranes occur at local peptide concentrations close to full membrane coverage. In this work we fully develop an interaction model of antimicrobial peptides with biological membranes; by exploring the consequences of the underlying partition formalism we arrive at a relationship that provides antibacterial activity prediction from two biophysical parameters: the affinity of the peptide to the membrane and the critical bound peptide to lipid ratio. A straightforward and robust method to implement this relationship, with potential application to high-throughput screening approaches, is presented and tested. In addition, disruptive thresholds in model membranes and the onset of antibacterial peptide activity are shown to occur over the same range of locally bound peptide concentrations (10 to 100 mM), which conciliates the two types of observations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.