ArticlePloS one2011
De novo growth zone formation from fission yeast spheroplasts.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Gut yeasts accelerate chill coma recovery in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- Live yeasts accelerate Drosophila melanogaster larval development.The Journal of experimental biology · 2024Article
- Eng2, a new player involved in feedback loop regulation of Cdc42 activity in fission yeast.Scientific reports · 2021Article
- Review
- MCHM Acts as a Hydrotrope, Altering the Balance of Metals in Yeast.Biological trace element research · 2020Article
- Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase.PLoS biology · 2020Article
- Reversible solidification of fission yeast cytoplasm after prolonged nutrient starvation.Journal of cell science · 2019Article
- Systematic mapping of cell wall mechanics in the regulation of cell morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy.eLife · 2016Article
- Wall mechanics and exocytosis define the shape of growth domains in fission yeast.Nature communications · 2015Article
- De novo morphogenesis in L-forms via geometric control of cell growth.Molecular microbiology · 2014Article
- How and why cells grow as rods.BMC biology · 2014Review
- Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.Trends in cell biology · 2013Review
- Compartmentalized nodes control mitotic entry signaling in fission yeast.Molecular biology of the cell · 2013Article
- Model of fission yeast cell shape driven by membrane-bound growth factors and the cytoskeleton.PLoS computational biology · 2013Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Eukaryotic cells often form polarized growth zones in response to internal or external cues. To understand the establishment of growth zones with specific dimensions we used fission yeast, which grows as a rod-shaped cell of near-constant width from growth zones located at the cell tips. Removing the cell wall creates a round spheroplast with a disorganized cytoskeleton and depolarized growth proteins. As spheroplasts recover, new growth zones form that resemble normal growing cell tips in shape and width, and polarized growth resumes. Regulators of the GTPase Cdc42, which control width in exponentially growing cells, also control spheroplast growth zone width. During recovery the Cdc42 scaffold Scd2 forms a polarized patch in the rounded spheroplast, demonstrating that a growth zone protein can organize independent of cell shape. Rga4, a Cdc42 GTPase activating protein (GAP) that is excluded from cell tips, is initially distributed throughout the spheroplast membrane, but is excluded from the growth zone after a stable patch of Scd2 forms. These results provide evidence that growth zones with normal width and protein localization can form de novo through sequential organization of cellular domains, and that the size of these growth zones is genetically controlled, independent of preexisting cell shape.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.