ArticleImmune network2011
Deficiency of foxp3 regulatory T cells exacerbates autoimmune arthritis by altering the synovial proportions of CD4 T cells and dendritic cells.
Article in Immune network, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Immuno-Modulatory Activities of Pentaherbs Formula on Ovalbumin-Induced Allergic Rhinitis Mice via the Activation of Th1 and Treg Cells and Inhibition of Th2 and Th17 Cells.Molecules (Basel, Switzerland) · 2021Article
- Characterization of the interaction between astrocytes and encephalitogenic lymphocytes during the development of experimental autoimmune encephalitomyelitis (EAE) in mice.Clinical and experimental immunology · 2012Article
- Rheumatoid Fibroblast-like Synoviocytes Downregulate Foxp3 Expression by Regulatory T Cells Via GITRL/GITR Interaction.Immune network · 2012Article
- Pathways for bone loss in inflammatory disease.Current osteoporosis reports · 2012Review
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4 authors.
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Abstract
backgroundCD4(+)Fop3(+) regulatory T cells (Tregs) are needed to maintain peripheral tolerance, but their role in the development of autoimmune arthritis is still debated. The present study was undertaken to investigate the mechanism by which Tregs influence autoimmune arthritis, using a mouse model entitled K/BxN.
methodsWe generated Treg-deficient K/BxNsf mice by congenically crossing K/BxN mice with Foxp3 mutant scurfy mice. The arthritic symptoms of the mice were clinically and histopathologically examined. The proportions and activation of CD4(+) T cells and/or dendritic cells were assessed in the spleens, draining lymph nodes and synovial tissue of these mice.
resultsK/BxNsf mice exhibited earlier onset and more aggressive progression of arthritis than their K/BxN littermates. In particular, bone destruction associated with the influx of numerous RANKL+ cells into synovia was very prominent. They also contained more memory phenotype CD4(+) T cells, more Th1 and Th2 cells, and fewer Th17 cells than their control counterparts. Plasmacytoid dendritic cells expressing high levels of CD86 and CD40 were elevated in the K/BxNsf synovia.
conclusionWe conclude that Tregs oppose the progression of arthritis by inhibiting the development of RANKL(+) cells, homeostatically proliferating CD4(+) T cells, Th1, Th2 and mature plasmacytoid dendritic cells, and by inhibiting their influx into joints.
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