ArticlePLoS genetics2011
HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 78 citations in OpenAlex.
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- Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans.PloS one · 2024Article
- Transcriptomic Profiling and Pathway Analysis of Mesenchymal Stem Cells Following Low Dose-Rate Radiation Exposure.Antioxidants (Basel, Switzerland) · 2023Article
- Guanxin V attenuates myocardial ischaemia reperfusion injury through regulating iron homeostasis.Pharmaceutical biology · 2022Article
- Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons.Nature communications · 2022Article
- A new ferritin SjFer0 affecting the growth and development of Schistosoma japonicum.Parasites & vectors · 2022Article
- Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans.PLoS genetics · 2021Article
- TOR functions as a molecular switch connecting an iron cue with host innate defense against bacterial infection.PLoS genetics · 2021Article
- Structural and functional relationship of mammalian and nematode ferritins.Biotechnologia · 2021Review
- Pulse magnetization elicits differential gene expression in the central nervous system of the Caribbean spiny lobster, Panulirus argus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- How affinity of the ELT-2 GATA factor binding toDevelopment (Cambridge, England) · 2020Article
- Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans.Redox biology · 2020Article
- Jian-Pi-Yi-Shen Regulates EPO and Iron Recycling Protein Expressions in Anemic Rats with Chronic Kidney Disease: Accumulation of Hypoxia Inducible Factor-2Evidence-based complementary and alternative medicine : eCAM · 2020Article
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- Reconstructing a metazoan genetic pathway with transcriptome-wide epistasis measurements.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets.Frontiers in neuroscience · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Caenorhabditis elegans ftn-1 and ftn-2, which encode the iron-storage protein ferritin, are transcriptionally inhibited during iron deficiency in intestine. Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 and ftn-2 promoters, but the mechanism for iron regulation is unknown. Here, we identify HIF-1 (hypoxia-inducible factor -1) as a negative regulator of ferritin transcription. HIF-1 binds to hypoxia-response elements (HREs) in the IDE in vitro and in vivo. Depletion of hif-1 by RNA interference blocks transcriptional inhibition of ftn-1 and ftn-2 reporters, and ftn-1 and ftn-2 mRNAs are not regulated in a hif-1 null strain during iron deficiency. An IDE is also present in smf-3 encoding a protein homologous to mammalian divalent metal transporter-1. Unlike the ftn-1 IDE, the smf-3 IDE is required for HIF-1-dependent transcriptional activation of smf-3 during iron deficiency. We show that hif-1 null worms grown under iron limiting conditions are developmentally delayed and that depletion of FTN-1 and FTN-2 rescues this phenotype. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.
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Registered trials
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