ArticlePLoS computational biology2011
Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- A nested bistable module within a negative feedback loop ensures different types of oscillations in signaling systems.Scientific reports · 2023Article
- Multi-Dimensional Analysis of Biochemical Network Dynamics Using pyDYVIPAC.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Crosstalk and ultrasensitivity in protein degradation pathways.PLoS computational biology · 2020Article
- LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy.Nature communications · 2019Article
- Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR.Scientific reports · 2018Article
- PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.Cell cycle (Georgetown, Tex.) · 2018Article
- Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression.Science advances · 2017Article
- Intermediates, catalysts, persistence, and boundary steady states.Journal of mathematical biology · 2017Article
- Boosting functionality of synthetic DNA circuits with tailored deactivation.Nature communications · 2016Article
- The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.Scientific reports · 2015Article
- DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks.Scientific reports · 2015Article
- Finding the positive feedback loops underlying multi-stationarity.BMC systems biology · 2015Article
- Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device.Cell cycle (Georgetown, Tex.) · 2015Article
- USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.Cell cycle (Georgetown, Tex.) · 2015Article
- Ubiquitin chain specific auto-ubiquitination triggers sustained oscillation, bistable switches and excitable firing.IET systems biology · 2014Article
- Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation.Frontiers in physiology · 2014Article
- When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.Cell communication and signaling : CCS · 2013Review
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for proteosomal degradation. Using biochemical data and computational modeling, we show that the Ring1B ligase can exhibit abrupt switches, overshoot transitions and self-perpetuating oscillations between its distinct ubiquitination and activity states. These different Ring1B states display canonical or multiply branched, atypical polyubiquitin chains and involve association with the Polycomb-group protein Bmi1. Bistable switches and oscillations may lead to all-or-none histone H2A monoubiquitination rates and result in discrete periods of gene (in)activity. Switches, overshoots and oscillations in Ring1B catalytic activity and proteosomal degradation are controlled by the abundances of Bmi1 and Ring1B, and the activities and abundances of external ligases and deubiquitinases, such as E6-AP and USP7.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.