ArticleMolecular vision2011
Replication study of significant single nucleotide polymorphisms associated with myopia from two genome-wide association studies.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Polymorphism in the 11q24.1 genomic region is associated with myopia: a comprehensive genetic study in Chinese and Japanese populations.Molecular vision · 2014Pooled it
- Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium.Human genetics · 2012Pooled it
- Genetic Association Study Revealed Three Loci Were Associated Risk of Myopia Among Minors.Pharmacogenomics and personalized medicine · 2021Article
- Insight into the molecular genetics of myopia.Molecular vision · 2017Review
- A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.Molecular vision · 2013Article
- Investigating the relationship between UMODL1 gene polymorphisms and high myopia: a case-control study in Chinese.BMC medical genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTwo previous genome-wide association studies (GWAS) of high myopia in a Japanese population found several single nucleotide polymorphisms (SNPs) associated with the disease. The present study examined whether these markers are associated with myopia in a Chinese population.
methodsIndividuals with or without complex myopia were recruited from Chinese university students, and probands with early onset high myopia were identified in the Pediatric and Genetic Eye Clinic of the Zhongshan Ophthalmic Center. DNA was prepared from venous leukocytes. Three SNPs, rs577948 and rs11218544 at chromosome position 11q24.1 and rs2839471 at chromosome position 21q22.3, were genotyped. The allele and genotype frequencies of these SNPs were compared between the myopia cases and controls using a χ(2) test.
resultsA total of 2,870 subjects were examined in this study, including 1,255 individuals with complex myopia (-10.00 diopter (D)<spherical refraction≤-4.00 D), 563 with early onset high myopia (spherical refraction≤-6.00 D), and 1,052 healthy controls (-0.50 D≤spherical equivalent≤ +2.00 D). There were no statistically significant differences found for the genotype or allele frequencies of the three SNPs between the myopia cases and controls in the Chinese population under study.
conclusionsWe did not find evidence for the association of myopia with rs577948, rs11218544, or rs2839471 in the Chinese population studied.
Indexed as
Identifiers
22194655PMC3244484W286307657What OpenQuestion holds
Registered trials
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