ArticleJournal of bacteriology2012
Derepression of the Bacillus subtilis PerR peroxide stress response leads to iron deficiency.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 73 citations in OpenAlex.
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- Extracellular Molecular Repertoire of Xerotolerant Actinobacteria Colonizing Serpentinite Rocks.International journal of molecular sciences · 2026Article
- Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025Review
- PerR: A Peroxide Sensor Eliciting Metal Ion-dependent Regulation in Various Bacteria.Molecular biotechnology · 2025Review
- Defense arsenal of the strict anaerobemBio · 2025Article
- Metals in Motion: Understanding Labile Metal Pools in Bacteria.Biochemistry · 2025Review
- 8-OxoG-Dependent Regulation of Global Protein Responses Leads to Mutagenesis and Stress Survival inAntioxidants (Basel, Switzerland) · 2024Article
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- Regulation of heme biosynthesis via the coproporphyrin dependent pathway in bacteria.Frontiers in microbiology · 2024Review
- The Arsenal ofAntioxidants (Basel, Switzerland) · 2023Review
- Meddling with Metal Sensors: Fur-Family Proteins as Signaling Hubs.Journal of bacteriology · 2023Review
- Iron homeostasis inMicrobiology (Reading, England) · 2023Article
- Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance.Microbiology spectrum · 2022Article
- Manganese impairs the QoxABCD terminal oxidase leading to respiration-associated toxicity.Molecular microbiology · 2021Article
- How Microbes Defend Themselves From Incoming Hydrogen Peroxide.Frontiers in immunology · 2021Review
- Improving the Cathodic Biofilm Growth Capabilities ofMicroorganisms · 2020Article
- Bacillus subtilis Fur Is a Transcriptional Activator for the PerR-RepressedJournal of bacteriology · 2020Article
- Dysregulation of Magnesium Transport Protects Bacillus subtilis against Manganese and Cobalt Intoxication.Journal of bacteriology · 2020Article
- Heme catabolism in the causative agent of anthrax.Molecular microbiology · 2019Article
- Manganese Detoxification by MntE Is Critical for Resistance to Oxidative Stress and Virulence ofmBio · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Bacillus subtilis PerR repressor regulates the adaptive response to peroxide stress. The PerR regulon includes the major vegetative catalase (katA), an iron storage protein (mrgA), an alkylhydroperoxide reductase (ahpCF), a zinc uptake system (zosA), heme biosynthesis enzymes (hemAXCDBL), the iron uptake repressor (fur), and perR itself. A perR null strain is resistant to hydrogen peroxide, accumulates a porphyrin-like compound, and grows very slowly. The poor growth of the perR mutant can be largely accounted for by the elevated expression of two proteins: the KatA catalase and Fur. Genetic studies support a model in which poor growth of the perR null mutant is due to elevated repression of iron uptake by Fur, exacerbated by heme sequestration by the abundant catalase protein. Analysis of the altered-function allele perR991 further supports a link between PerR and iron homeostasis. Strains containing perR991 are peroxide resistant but grow nearly as well as the wild type. Unlike a perR null allele, the perR991 allele (F51S) derepresses KatA, but not Fur, which likely accounts for its comparatively rapid growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.