ArticleJournal of cell science2011
Cellular self-organization by autocatalytic alignment feedback.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Engineering anisotropic tissues: from structured scaffolds to magnetic actuation.Materials today. Bio · 2026Review
- Exploring the piezoelectric phenomenon: From polymers to human tissues and advanced applications in tissue engineering.Bioactive materials · 2026Review
- Article
- Integer topological defects organize stresses driving tissue morphogenesis.Nature materials · 2022Article
- Explicit calculation method for cell alignment in non-circular geometries.Royal Society open science · 2022Article
- Multiscale-Engineered Muscle Constructs: PEG Hydrogel Micro-Patterning on an Electrospun PCL Mat Functionalized with Gold Nanoparticles.International journal of molecular sciences · 2021Article
- AnTheranostics · 2021Article
- Towards an analytical description of active microswimmers in clean and in surfactant-covered drops.The European physical journal. E, Soft matter · 2020Article
- Engineering macroscale cell alignment through coordinated toolpath design using support-assisted 3D bioprinting.Journal of the Royal Society, Interface · 2020Article
- Building Complex Life Through Self-Organization.Tissue engineering. Part A · 2019Review
- Nanotopography-responsive myotube alignment and orientation as a sensitive phenotypic biomarker for Duchenne Muscular Dystrophy.Biomaterials · 2018Article
- Outline-etching image segmentation reveals enhanced cell chirality through intercellular alignment.Biotechnology and bioengineering · 2018Article
- Regulation of skeletal myotube formation and alignment by nanotopographically controlled cell-secreted extracellular matrix.Journal of biomedical materials research. Part A · 2018Article
- Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts.Science advances · 2018Article
- Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.PLoS computational biology · 2016Article
- Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement.Scientific reports · 2016Article
- Selectively manipulable acoustic-powered microswimmers.Scientific reports · 2015Article
- Probing mechanoregulation of neuronal differentiation by plasma lithography patterned elastomeric substrates.Scientific reports · 2014Article
- Mechanically induced intercellular calcium communication in confined endothelial structures.Biomaterials · 2013Article
- Preferred mitotic orientation in pattern formation by vascular mesenchymal cells.American journal of physiology. Heart and circulatory physiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Myoblasts aggregate, differentiate and fuse to form skeletal muscle during both embryogenesis and tissue regeneration. For proper muscle function, long-range self-organization of myoblasts is required to create organized muscle architecture globally aligned to neighboring tissue. However, how the cells process geometric information over distances considerably longer than individual cells to self-organize into well-ordered, aligned and multinucleated myofibers remains a central question in developmental biology and regenerative medicine. Using plasma lithography micropatterning to create spatial cues for cell guidance, we show a physical mechanism by which orientation information can propagate for a long distance from a geometric boundary to guide development of muscle tissue. This long-range alignment occurs only in differentiating myoblasts, but not in non-fusing myoblasts perturbed by microfluidic disturbances or other non-fusing cell types. Computational cellular automata analysis of the spatiotemporal evolution of the self-organization process reveals that myogenic fusion in conjunction with rotational inertia functions in a self-reinforcing manner to enhance long-range propagation of alignment information. With this autocatalytic alignment feedback, well-ordered alignment of muscle could reinforce existing orientations and help promote proper arrangement with neighboring tissue and overall organization. Such physical self-enhancement might represent a fundamental mechanism for long-range pattern formation during tissue morphogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.