ArticleJournal of cell science2011
A feedback loop between Wolbachia and the Drosophila gurken mRNP complex influences Wolbachia titer.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Thermal sensitivity in a symbiont: effect of elevated cyclic temperature exposure on Wolbachia density in Culex quinquefasciatus (Diptera: Culicidae) embryos.Journal of insect science (Online) · 2026Article
- Fexinidazole and Corallopyronin A target Wolbachia-infected sheath cells present in filarial nematodes.PLoS pathogens · 2025Article
- Comparative analysis of Wolbachia maternal transmission and localization in host ovaries.Communications biology · 2024Article
- Comparative analysis ofbioRxiv : the preprint server for biology · 2024Article
- A Light in the Dark: Uncovering Wolbachia-Host Interactions Using Fluorescence Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The cellular lives of Wolbachia.Nature reviews. Microbiology · 2023Review
- Distinct Wolbachia localization patterns in oocytes of diverse host species reveal multiple strategies of maternal transmission.Genetics · 2023Article
- Article
- Restriction ofmBio · 2022Article
- Population Dynamics of Wolbachia in the Leafhopper Vector Yamatotettix flavovittatus (Hemiptera: Cicadellidae).Journal of insect science (Online) · 2021Article
- Bacterial Symbionts of Tsetse Flies: Relationships and Functional Interactions Between Tsetse Flies and Their Symbionts.Results and problems in cell differentiation · 2020Review
- Trends in Symbiont-Induced Host Cellular Differentiation.Results and problems in cell differentiation · 2020Article
- Quantitative methods for assessing local and bodywide contributions to Wolbachia titer in maternal germline cells of Drosophila.BMC microbiology · 2019Article
- Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling.Nature communications · 2018Article
- Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation.PLoS pathogens · 2018Article
- Wolbachia and host germline components compete for kinesin-mediated transport to the posterior pole of the Drosophila oocyte.PLoS pathogens · 2018Article
- The Maternal Effect Gene Wds Controls Wolbachia Titer in Nasonia.Current biology : CB · 2018Article
- Population genomics of Wolbachia and mtDNA in Drosophila simulans from California.Scientific reports · 2017Article
- Dietary saccharides and sweet tastants have differential effects on colonization ofBiology open · 2017Article
- Reliance ofGenetics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Although much is known about interactions between bacterial endosymbionts and their hosts, little is known concerning the host factors that influence endosymbiont titer. Wolbachia endosymbionts are globally dispersed throughout most insect species and are the causative agent in filarial nematode-mediated disease. Our investigation indicates that gurken (grk), a host gene encoding a crucial axis determinant, has a cumulative, dosage-sensitive impact on Wolbachia growth and proliferation during Drosophila oogenesis. This effect appears to be mediated by grk mRNA and its protein-binding partners Squid and Hrp48/Hrb27C, implicating the grk mRNA-protein (mRNP) complex as a rate-limiting host factor controlling Wolbachia titer. Furthermore, highly infected flies exhibit defects that match those occurring with disruption of grk mRNPs, such as nurse cell chromatin disruptions and malformation of chorionic appendages. These findings suggest a feedback loop in which Wolbachia interaction with the grk mRNP affects both Wolbachia titer and grk mRNP function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.