Evidence map›Paper›PMID 22193780›Full record

Trial reportJournal of cancer survivorship : research and practice2012

The effect of resistance training on muscle strength and physical function in older, postmenopausal breast cancer survivors: a randomized controlled trial.

Kerri M Winters-Stone, Jessica Dobek, Jill A Bennett, Lillian M Nail, Michael C Leo, Anna Schwartz

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cancer survivorship : research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 103 papers, 29 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 29 pooled it
19.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00591747 nacompletednot on this map

Strength Training for Older Breast Cancer Survivors

TypeinterventionalSponsorOHSU Knight Cancer InstituteRan2005 to 2011Enrolled106ConditionsBreast Neoplasm, Osteoporosis, PostmenopausalArmsResistance Exercise, Flexibility Training
NCT01954706 naterminatednot on this mapstarted 2013, after this paper: background citation

Pilot Trial of Aerobic and Resistance Exercise Training for the Primary Prevention of Musculoskeletal Side Effects From Aromatase Inhibitors in Postmenopausal Breast Cancer Patients

TypeinterventionalSponsorBaltimore VA Medical CenterRan2013 to 2015Enrolled5ConditionsBreast Cancer, SarcopeniaArmsStructured Exercise, Usual Care
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 29 syntheses or guidelines pooled it, 205 citations in OpenAlex.

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  9. Resistance training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2024
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  20. Exercise for reducing falls in people living with and beyond cancer.The Cochrane database of systematic reviews · 2018
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kerri M Winters-StoneSchool of Nursing, Oregon Health and Science University, 3455 SW US Veteran's Hospital Rd, Mailcode: SN-ORD, Portland, OR 97239, USA. wintersk@ohsu.edu
Jessica Dobek
Jill A Bennett
Lillian M Nail
Michael C Leo
Anna Schwartz
Oregon Health & Science University · USIdaho State University · US

Funding

OREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Comparison of Aerobic and Resistance Exercise in Older Breast Cancer SurvivorsR01CA120123 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI WINTERS-STONE, KERRI M · 2007 to 2009
$849k
NCATS NIH HHS UL1 TR000128NCI NIH HHS 1R01 CA120123NCI NIH HHS R01 CA120123NCRR NIH HHS UL1 RR024140
6 · The paper itself

Abstract

introductionOlder breast cancer survivors (BCS) report more falls and functional limitations than women with no cancer history. Exercise training could reduce risk factors for future falls and disability.

methodsWe conducted a randomized, controlled trial in 106 early-stage, postmenopausal BCS who were ≥50 years old at diagnosis and post-treatment. Women were randomly assigned to a 1-year resistance + impact exercise program or a stretching placebo program. Endpoints were one repetition maximum bench press and leg press strength, timed five chair stands, 4 m usual walk speed, timed stance tests, handgrip strength, self-report physical function, and fatigue. We also examined the influence of age, adjuvant hormone therapy use, and exercise adherence on study outcomes.

resultsWomen in the resistance + impact training program significantly improved maximal leg (p <0 .02) and bench (p <0 .02) press strength compared to the stretching group. Women who attended 50% or more of prescribed resistance training sessions had significantly better changes in maximal strength measures compared to less adherent women.

conclusionsResistance + impact exercise is superior to stretching at improving maximal muscle strength and exercise adherence contributes to the degree of improvement. IMPLICATIONS FOR CANCER SURVIVORS: Older BCS can safely engage in resistance exercise that improves lower and upper body strength, thereby reducing a risk factor for falls and future disability. However, the ability of resistance training to shift other indices of fall and disability risk, i.e., balance and function, is unclear. Strategies to promote adherence to resistance training could lead to greater improvements in strength.

Indexed as

Exercise TherapyPostmenopauseResistance TrainingSurvivorsAgedAged, 80 and overBreast NeoplasmsFemaleHand StrengthHumansMiddle AgedMuscle StrengthNeoplasm StagingPrognosisSingle-Blind Method

Identifiers

PMID22193780
PMCPMC3488606
OpenAlexW2045462605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.