ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Effects of morphine on thermal sensitivity in adult and aged rats.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Dexamethasone reduces postoperative pain while delays wound healing in an animal model: Involvement of the NLRP3/Caspase-1/IL-1β pathway.BMC anesthesiology · 2026Article
- Automated thermal gradient test for unprovoked assessment of nociceptive preference in rodents.Frontiers in behavioral neuroscience · 2025Article
- Complex alterations in inflammatory pain and analgesic sensitivity in young and ageing female rats: involvement of ASIC3 and Nav1.8 in primary sensory neurons.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Rats chasing the dragon: A new heroin inhalation method.Journal of neuroscience methods · 2024Article
- Behavioral and pharmacological characterization of planarian nociception.Frontiers in molecular neuroscience · 2024Article
- Aging reduces the sensitivity to the reinforcing efficacy of morphine.Neurobiology of aging · 2021Article
- Effects of Aging on Formalin-Induced Pain Behavior and Analgesic Activity of Gabapentin in C57BL/6 Mice.Frontiers in pharmacology · 2020Article
- Effects of buprenorphine in the adrenal, thyroid, and cytokine intra-operative responses in a rat model (Iranian journal of basic medical sciences · 2017Article
- Methods Used to Evaluate Pain Behaviors in Rodents.Frontiers in molecular neuroscience · 2017Article
- Thermal sensitivity across ages and during chronic fentanyl administration in rats.Psychopharmacology · 2014Article
- The effects of aging on hydromorphone-induced thermal antinociception in healthy female cats.Pain reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There are contradictory data regarding older individuals' sensitivity to pain stimulation and opioid administration. Adult (12-16 months; n = 10) and aged (27-31 months; n = 7) male F344xBN rats were tested in a thermal sensitivity procedure where the animal chooses to remain in one of two compartments with floors maintained at various temperatures ranging from hot (45°C) through neutral (30°C) to cold (15°C). Effects of morphine were determined for three temperature comparisons (ie, hot/neutral, cold/neutral, and hot/cold). Aged rats were more sensitive to cold stimulation during baseline. Morphine produced antinociception during hot thermal stimulation, but had no effect on cold stimulation. The antinociceptive (and locomotor-altering) effects of morphine were attenuated in aged rats. These data demonstrate age-related differences in baseline thermal sensitivity and responsiveness to opioids. Based on behavioral and physiological requirements of this procedure, it is suggested that thermal sensitivity may provide a relevant animal model for the assessment of pain and antinociception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.