ReviewJournal of the American College of Cardiology2012
Hypoplastic left heart syndrome: current considerations and expectations.
Review in Journal of the American College of Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 194 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
194 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Innovations in transcatheter interventions for hypoplastic left heart syndrome and borderline left heart structures from fetal to neonatal life: current evidence and systematic review of recent advances (2016-2025).European journal of pediatrics · 2026Pooled it
- Cognitive Function in Pediatric Hypoplastic Left Heart Syndrome: Systematic Review and Meta-Analysis.Journal of pediatric psychology · 2019Pooled it
- Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis.Pediatric cardiology · 2020Trial
- Fetal aortic valvuloplasty for evolving hypoplastic left heart syndrome: postnatal outcomes of the first 100 patients.Circulation · 2014Trial
- Protein-losing enteropathy in a child with hypoplastic left heart syndrome after Fontan palliation: a case report.Oxford medical case reports · 2026Article
- Computational Modeling of Oxygen Delivery in Norwood Physiology: Differential Effects of Systemic and Pulmonary Vasodilator Conditions.Journal of cardiovascular development and disease · 2026Article
- Kawashima procedure without fenestration in a 5-month-old infant with functional single ventricle and interrupted inferior vena cava: a case report.Journal of surgical case reports · 2026Article
- Hypoplastic Left Heart Syndrome in U.S. Children: A 20-Year Look at Lives Lost and Gaps That Remain.Pediatric cardiology · 2026Article
- Neonatal Cerebrovascular Stability Index and Oxygenation With 3-Month Neurodevelopmental Outcomes.JACC. Advances · 2026Article
- Effects of ACE inhibitor and afterload reduction in single ventricles following bidirectional Glenn.Open heart · 2026Article
- Determination of cardiac output, shunt-fraction, and active circulatory volume in children with hypoplastic left heart syndrome after the Norwood procedure with RV to PA-shunt.Scientific reports · 2026Article
- A Patient-Specific Computational Model for Neonates and Infants with Borderline Left Ventricles.Annals of biomedical engineering · 2026Article
- Non-Newtonian blood rheology significantly alters hemodynamic predictions during cardiac looping: a computational study.Frontiers in bioengineering and biotechnology · 2026Article
- MRI Assessment of Energy Loss Within the Thoracic Aorta and Its Impact on Cardiac Function in Fontan Patients After Aortic Reconstruction.Journal of magnetic resonance imaging : JMRI · 2025Article
- Fetal Right Heart Strain in Systemic Right Ventricles and Impact on Post-surgical Outcomes.Pediatric cardiology · 2025Article
- Tracheostomy in patients with a single ventricle during stage 1 palliation hospitalization: Prudent?JTCVS techniques · 2025Article
- Prenatal Diagnosis and Decision-Making in Severe Pulmonary Stenosis With Coronary Sinusoids: A Case Report.Clinical case reports · 2025Article
- Review
- Preclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis.JACC. Basic to translational science · 2025Article
- Managing High Risk Pregnancy in Single Ventricle Physiology with Acquired von Willebrand Disease: A Case Report.Reports (MDPI) · 2025Article
134 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
28 authors.
Funding
Abstract
In the recent era, no congenital heart defect has undergone a more dramatic change in diagnostic approach, management, and outcomes than hypoplastic left heart syndrome (HLHS). During this time, survival to the age of 5 years (including Fontan) has ranged from 50% to 69%, but current expectations are that 70% of newborns born today with HLHS may reach adulthood. Although the 3-stage treatment approach to HLHS is now well founded, there is significant variation among centers. In this white paper, we present the current state of the art in our understanding and treatment of HLHS during the stages of care: 1) pre-Stage I: fetal and neonatal assessment and management; 2) Stage I: perioperative care, interstage monitoring, and management strategies; 3) Stage II: surgeries; 4) Stage III: Fontan surgery; and 5) long-term follow-up. Issues surrounding the genetics of HLHS, developmental outcomes, and quality of life are addressed in addition to the many other considerations for caring for this group of complex patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.