ArticleBioorganic & medicinal chemistry letters2012
Pharmacophore-based discovery of a novel cytosolic phospholipase A(2)α inhibitor.
Article in Bioorganic & medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Pharmacophore-guided Virtual Screening to Identify New βMolecular informatics · 2022Article
- In Silico Drug Discovery for Treatment of Virus Diseases.Advances in experimental medicine and biology · 2022Article
- In silico virtual screening approaches for anti-viral drug discovery.Drug discovery today. Technologies · 2012Article
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Authors and funding
9 authors.
Funding
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Abstract
The release of arachidonic acid, a precursor in the production of prostaglandins and leukotrienes, is achieved by activity of the cytosolic phospholipase A(2)α (cPLA(2)α). Signaling mediated by this class of bioactive lipids, which are collectively referred to as eicosanoids, has numerous effects in physiological and pathological processes. Herein, we report the development of a ligand-based pharmacophore model and pharmacophore-based virtual screening of the National Cancer Institute (NCI) database, leading to the identification of 4-(hexadecyloxy)-3-(2-(hydroxyimino)-3-oxobutanamido)benzoic acid (NSC 119957) as cPLA(2)α inhibitor in cell-free and cell-based in vitro assays.
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