ArticleCellular immunology2012
HIF-1α signaling by airway epithelial cell K-α1-tubulin: role in fibrosis and chronic rejection of human lung allografts.
Article in Cellular immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 32 citations in OpenAlex.
- The role of lung-restricted autoantibodies in the development of primary and chronic graft dysfunction.Frontiers in transplantation · 2023Review
- Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective.Biomedicines · 2022Review
- Clinical relevance of lung-restricted antibodies in lung transplantation.Human immunology · 2019Review
- The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation.Journal of cardiothoracic surgery · 2019Article
- High salt induces P-glycoprotein mediated treatment resistance in breast cancer cells through store operated calcium influx.Oncotarget · 2018Article
- Circulating Exosomes with Distinct Properties during Chronic Lung Allograft Rejection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Potential anticancer effect of prostratin through SIK3 inhibition.Oncology letters · 2018Article
- Immune Responses to Tissue-Restricted Nonmajor Histocompatibility Complex Antigens in Allograft Rejection.Journal of immunology research · 2017Review
- Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation.PloS one · 2017Article
- Lung-Restricted Antibodies Mediate Primary Graft Dysfunction and Prevent Allotolerance after Murine Lung Transplantation.American journal of respiratory cell and molecular biology · 2016Article
- Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells.Cell biochemistry and biophysics · 2016Article
- NFAT5/STAT3 interaction mediates synergism of high salt with IL-17 towards induction of VEGF-A expression in breast cancer cells.Oncology letters · 2016Article
- Autoimmune Reactivity in Graft Injury: Player or Bystander?Current transplantation reports · 2015Article
- Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: potential role in liver fibrosis.Molecular immunology · 2015Article
- Safety and preliminary evidence of biologic efficacy of a mammaglobin-a DNA vaccine in patients with stable metastatic breast cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Immune response to tissue-restricted self-antigens induces airway inflammation and fibrosis following murine lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2014Article
- Protective role of bortezomib in steatotic liver ischemia/reperfusion injury through abrogation of MMP activation and YKL-40 expression.Transplant immunology · 2014Article
- Moving beyond HLA: a review of nHLA antibodies in organ transplantation.Human immunology · 2013Review
- Interplay between immune responses to HLA and non-HLA self-antigens in allograft rejection.Human immunology · 2013Review
- Pre-transplant antibodies to Kα1 tubulin and collagen-V in lung transplantation: clinical correlations.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Long term survival of the human lung allografts are hindered by chronic rejection, manifested clinically as bronchiolitis obliterans syndrome (BOS). We previously demonstrated significant correlation between the development of antibodies (Abs) to K-α1-tubulin (Kα1T) and BOS. In this study, we investigated the molecular basis for fibrinogenesis mediated by ligation of Kα1T expressed on airway epithelial cells by its specific Abs. Using RT-PCR we demonstrate that normal human bronchial epithelial (NHBE) cells upon ligation of Kα1T with specific Abs caused upregulation of pro-fibrotic growth factors. Western blot analysis of NHBE incubated with Kα1T Abs increased hypoxia inducible factor (HIF-1α). Kα1T Ab-mediated growth factor expression is dependent on HIF-1α as inhibition of HIF-1α returned fibrotic growth factor expression to basal levels. In conclusion, we propose that HIF-1α -mediated upregulation of fibrogenic growth factors induced by ligation of Kα1T Abs is critical for development of fibrosis leading to chronic rejection of lung allograft.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.