ArticleJACC. Cardiovascular interventions2011
Closed-chest transthoracic magnetic resonance imaging-guided ventricular septal defect closure in swine.
Article in JACC. Cardiovascular interventions, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Interventional cardiac magnetic resonance imaging: current applications, technology readiness level, and future perspectives.Therapeutic advances in cardiovascular diseasePooled it
- Hybrid approach: a prospective option for treating congenital heart defects in pediatric patients.Frontiers in cardiovascular medicine · 2025Review
- Advancements in Cardiac Catheterization Safety: Novel Radiation Protection Approaches Redefining Occupational Health.Current cardiology reviews · 2025Review
- MRI-guided endovascular intervention: current methods and future potential.Expert review of medical devices · 2022Review
- MRI-Guided Cardiac Catheterization in Congenital Heart Disease: How to Get Started.Current cardiology reports · 2022Review
- MRI Catheterization: Ready for Broad Adoption.Pediatric cardiology · 2020Review
- Magnetic Resonance Imaging-Guided Transcatheter Cavopulmonary Shunt.JACC. Cardiovascular interventions · 2016Article
- Interventional CMR: Clinical applications and future directions.Current cardiology reports · 2015Review
- MRI catheterization in cardiopulmonary disease.Chest · 2014Article
- Real-time cardiovascular magnetic resonance subxiphoid pericardial access and pericardiocentesis using off-the-shelf devices in swine.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2013Article
- Real-time MRI-guided right heart catheterization in adults using passive catheters.European heart journal · 2013Article
- Transthoracic delivery of large devices into the left ventricle through the right ventricle and interventricular septum: preclinical feasibility.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2013Article
- Active delivery cable tuned to device deployment state: enhanced visibility of nitinol occluders during preclinical interventional MRI.Journal of magnetic resonance imaging : JMRI · 2012Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe aim of this study was to close ventricular septal defects (VSDs) directly through the chest wall using magnetic resonance imaging (MRI) guidance, without cardiopulmonary bypass, sternotomy, or radiation exposure.
backgroundSurgical, percutaneous, and hybrid management of VSD each have limitations and known morbidity.
methodsPercutaneous muscular VSDs were created in 10 naive Yorkshire swine using a transjugular laser catheter. Under real-time MRI guidance, a direct transthoracic vascular access sheath was introduced through the chest into the heart along a trajectory suitable for VSD access and closure. Through this transthoracic sheath, muscular VSDs were occluded using a commercial nitinol device. Finally, the right ventricular free wall was closed using a commercial collagen plug intended for arterial closure.
resultsAnterior, posterior, and mid-muscular VSDs (6.8 ± 1.8 mm) were created. VSDs were closed successfully in all animals. The transthoracic access sheath was displaced in 2, both fatal. Thereafter, we tested an intracameral retention sheath to prevent this complication. Right ventricular access ports were closed successfully in all, and after as many as 30 days, healed successfully.
conclusionsReal-time MRI guidance allowed closed-chest transthoracic perventricular muscular VSD closure in a clinically meaningful animal model. Once applied to patients, this approach may avoid traditional surgical, percutaneous, or open-chest transcatheter ("hybrid") risks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.