ArticleCardiovascular diabetology2011
A structural equation model for assessment of links between changes in serum triglycerides, -urate, and -glucose and changes in serum calcium, -magnesium and -phosphate in type 2 diabetes and non-diabetes metabolism.
Article in Cardiovascular diabetology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Non-traditional risk factors for coronary calcification and its progression in patients with type 2 diabetes: The impact of postprandial glycemia and fetuin-A.The Journal of international medical research · 2019Trial
- Sexual dimorphisms in serum calcium and phosphate concentrations in the Rotterdam Study.Scientific reports · 2023Article
- Importance of serum phosphate in elderly patients with diabetes mellitus.World journal of diabetes · 2020Article
- Evaluation of Electrolytes Imbalance and Dyslipidemia in Diabetic Patients.Medical sciences (Basel, Switzerland) · 2016Article
- Structural equation model for estimating risk factors in type 2 diabetes mellitus in a Middle Eastern setting: evidence from the STEPS Qatar.BMJ open diabetes research & care · 2016Article
- High serum phosphate and triglyceride levels in smoking women and men with CVD risk and type 2 diabetes.Diabetology & metabolic syndrome · 2014Article
- A new strategy for early diagnosis of type 2 diabetes by standard-free, label-free LC-MS/MS quantification of glycated peptides.Diabetes · 2013Article
- Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus.Cardiovascular diabetology · 2013Article
- Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes.Cardiovascular diabetology · 2013Article
- Vitamin D supplementation as an adjuvant therapy for patients with T2DM: an 18-month prospective interventional study.Cardiovascular diabetology · 2012Article
- Low serum magnesium concentrations are associated with a high prevalence of premature ventricular complexes in obese adults with type 2 diabetes.Cardiovascular diabetology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigates the associations between changes in serum triglycerides (S-TG), -urate (S-Urate), and -glucose (S-Glu) and changes in serum calcium (S-Ca), -magnesium (S-Mg), and -phosphate (S-P) in patients with type 2 diabetes compared with non-diabetic patients.
methodsThe analysis is based on data collected from a secondary prevention population of women and men (W/M) at risk for cardiovascular disease (type 2 diabetes, 212/200; non-diabetes 968/703). The whole population (n = 2083) had a mean age of 51.0 (9.7) years and was stratified for sex and according to type 2 diabetes or non-diabetes. The patients were followed for, either half a year or one year and changes in risk factors were calculated from follow-up to baseline, the time when patients were admitted to the health center. The pattern of relationships was evaluated using a structural equation model.
resultsHigher S-TG and S-Glu but lower S-Urate was revealed at baseline in type 2 diabetes women and men as compared to their counterparts, non-diabetes patients. Women with type 2 diabetes had higher S-Ca and lower S-Mg than non-diabetes women. Changes in S-Glu were associated with changes in S-Ca (+), baseline S-Ca (+), and S-Urate (-) in type 2 diabetes men. Changes in S-Urate were associated with changes in S-Mg (+) in type 2 diabetes women and non-diabetes men. In men with non-diabetes, changes in S-Glu were associated with changes in S-Mg (-). In women with non-diabetes, changes in S-Glu were associated with changes in S-P (-) and changes in S-Urate with changes in S-Ca (+).
conclusionWith respect to metabolic disturbances in non-diabetes and the awareness of risk for type 2 diabetes, changes in S-Glu and changes in S-Ca, S-Mg, and S-P should be considered as risk factors for cardiovascular disease. Increased early detection and corrections of high S-Ca, low S-Mg, and S-P in obese patients may improve their metabolism and reduce the risk of CVD in patients with type 2 diabetes. TRIAL REGISTRATION NUMBER: ISRCTN: ISRCTN79355192.
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