ArticleAssay and drug development technologies2012
A bifunctional dimethylsulfoxide substitute enhances the aqueous solubility of small organic molecules.
Article in Assay and drug development technologies, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Evaluation of anthoxanthins and their actions on digestive enzyme inhibition when used independently and in combination.Heliyon · 2022Article
- Combined injury: irradiation with skin or bone wounds in rodent models.Journal of radiological protection : official journal of the Society for Radiological Protection · 2021Article
- Oxetanyl Sulfoxide MMS-350 Ameliorates Pulmonary FibrosisACS medicinal chemistry letters · 2020Article
- Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (FancaRadiation research · 2019Article
- A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis.ACS central science · 2016Article
- An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility.ACS medicinal chemistry letters · 2014Article
- Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells.Experimental hematology · 2013Article
- Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350).Radiation research · 2013Article
- Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines.In vivo (Athens, Greece)Article
- SARS-CoV-2 Spike Protein Induces Oxidative Stress and Senescence in Mouse and Human Lung.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
An oxetane-substituted sulfoxide has demonstrated potential as a dimethylsulfoxide substitute for enhancing the dissolution of organic compounds with poor aqueous solubilities. This sulfoxide may find utility in applications of library storage and biological assays. For the model compounds studied, significant solubility enhancements were observed using the sulfoxide as a cosolvent in aqueous media. Brine shrimp, breast cancer (MDA-MB-231), and liver cell line (HepG2) toxicity data for the new additive are also presented, in addition to comparative IC(50) values for a series of PKD1 inhibitors.
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Registered trials
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