ArticleAstrobiology2012
An exit cavity was crucial to the polymerase activity of the early ribosome.
Article in Astrobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Ribosomal proteins can hold a more accurate record of bacterial thermal adaptation compared to rRNA.Nucleic acids research · 2023Article
- How to build a protoribosome: structural insights from the first protoribosome constructs that have proven to be catalytically active.RNA (New York, N.Y.) · 2023Article
- Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds.Nucleic acids research · 2022Article
- The Peptidyl Transferase Center: a Window to the Past.Microbiology and molecular biology reviews : MMBR · 2021Article
- The Origin(s) of Cell(s): Pre-Darwinian Evolution from FUCAs to LUCA : To Carl Woese (1928-2012), for his Conceptual Breakthrough of Cellular Evolution.Journal of molecular evolution · 2021Article
- Further Characterization of the Pseudo-Symmetrical Ribosomal Region.Life (Basel, Switzerland) · 2020Article
- Experimental solutions to problems defining the origin of codon-directed protein synthesis.Bio Systems · 2019Review
- Systems protobiology: origin of life in lipid catalytic networks.Journal of the Royal Society, Interface · 2018Review
- The Central Symbiosis of Molecular Biology: Molecules in Mutualism.Journal of molecular evolution · 2017Review
- Frozen in Time: The History of Proteins.Molecular biology and evolution · 2017Article
- A Possible Role of the Full-Length Nascent Protein in Post-Translational Ribosome Recycling.PloS one · 2017Article
- History of the ribosome and the origin of translation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Ancient Systems of Sodium/Potassium Homeostasis as Predecessors of Membrane Bioenergetics.Biochemistry. Biokhimiia · 2015Article
- The ribosome challenge to the RNA world.Journal of molecular evolution · 2015Review
- How amino acids and peptides shaped the RNA world.Life (Basel, Switzerland) · 2015Review
- Evolution of the ribosome at atomic resolution.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The drive to life on wet and icy worlds.Astrobiology · 2014Article
- Nanometer scale pores similar in size to the entrance of the ribosomal exit cavity are a common feature of large RNAs.RNA (New York, N.Y.) · 2013Article
- Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of an RNA entity capable of synthesizing peptides was a key prebiotic development. It is hypothesized that a precursor of the modern ribosomal exit tunnel was associated with this RNA entity (e.g., "protoribosome" or "bonding entity") from the earliest time and played an essential role. Various compounds that can bind and activate amino acids, including extremely short RNA chains carrying amino acids, and possibly di- or tripeptides, would have associated with the internal cavity of the protoribosome. This cavity hosts the site for peptide bond formation and adjacent to it a relatively elongated feature that could have evolved to the modern ribosomal exit tunnel, as it is wide enough to allow passage of an oligopeptide. When two of the compounds carrying amino acids or di- or tripeptides (to which we refer, for simplicity, as small aminoacylated RNAs) were in proximity within the heart of the protoribosome, a peptide bond could form spontaneously. The growing peptide would enter the nearby cavity and would not disrupt the attachment of the substrates to the protoribosome or interfere with the subsequent attachment of additional small aminoacylated RNAs. Additionally, the presence of the peptide in the cavity would increase the lifetime of the oligopeptide in the protoribosome. Thus, subsequent addition of another amino acid would be more likely than detachment from the protoribosome, and synthesis could continue. The early ability to synthesize peptides may have resulted in an abbreviated RNA World.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.