ArticleOxidative medicine and cellular longevity2011
Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis.
Article in Oxidative medicine and cellular longevity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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31 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Exploring the efficacy of plant-based nutraceuticals in managing diabetic neuropathy.Inflammopharmacology · 2025Pooled it
- Article
- Date palm fruits (Frontiers in plant science · 2026Review
- Therapeutic Power of Date Fruit (Food science & nutrition · 2025Review
- Natural therapy proposed for the management of diabetic peripheral neuropathy (DPN).Inflammopharmacology · 2025Review
- MoSeq based 3D behavioral profiling uncovers neuropathic behavior changes in diabetic mouse model.Scientific reports · 2025Article
- Dates fruit effects on dyslipidemia among patients with Type-2 diabetes mellitus: A systematic review and meta-analysis of randomized trials.Pakistan journal of medical sciences · 2025Review
- A comparative neuro-study of solo or accompanied low and high boric acid doses with date molasses in adult male albino rats.Environmental analysis, health and toxicology · 2024Article
- Antigen B modulates anti-inflammatory cytokines in the EAE model of multiple sclerosis.Brain and behavior · 2023Article
- Date Fruits as Raw Material for Vinegar and Non-Alcoholic Fermented Beverages.Foods (Basel, Switzerland) · 2022Review
- Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling.Archives of pharmacal research · 2022Article
- Effect of Date Palm (Frontiers in neuroscience · 2022Article
- SMTP-44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti-inflammatory activities.Pharmacology research & perspectives · 2020Article
- Potentials and Safety of Date Palm Fruit against Diabetes: A Critical Review.Foods (Basel, Switzerland) · 2020Review
- Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities.Current research in food science · 2019Article
- Dexmedetomidine attenuates P2X4 and NLRP3 expression in the spine of rats with diabetic neuropathic pain.Acta cirurgica brasileira · 2019Article
- Article
- Review
- Date Palm Tree (Frontiers in plant science · 2017Review
- Date Palm (Frontiers in pharmacology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo study the effects of an aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) diet on diabetic polyneuropathy (DPN) in streptozotocin- (STZ-) induced diabetic rats.
methodsThe effects of a date fruit extract (DFE) diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with a nondiabetic control group, diabetic control group (sham), and vehicle group with respect to the following parameters: open field behavioral test, motor nerve conduction velocity (MNCV), and morphological observations.
resultsIn the model of STZ-induced of diabetic neuropathy, chronic treatment for 6 weeks with DFE counteracted the impairment of the explorative activity of the rats in an open field behavioral test and of the conduction velocity of the sciatic nerve (MNCV). In addition, pretreatment with DFE significantly reversed each nerve diameter reduction in diabetic rats.
conclusionDFE treatment shows efficacy for preventing diabetic deterioration and for improving pathological parameters of diabetic neuropathy in rats, as compared with control groups.
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