Evidence map›Paper›PMID 22191012›Full record

Trial reportOxidative medicine and cellular longevity2011

The effects of a multiflavonoid supplement on vascular and hemodynamic parameters following acute exercise.

Rebecca M Kappus, Chelsea D Curry, Steve McAnulty, Janice Welsh, David Morris, David C Nieman, Jeffrey Soukup, Scott R Collier

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Oxidative medicine and cellular longevity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rebecca M KappusVascular Biology and Autonomic Studies Laboratory, Appalachian State University, Boone, NC 28608, USA.
Chelsea D Curry
Steve McAnulty
Janice Welsh
David Morris
David C Nieman
Jeffrey Soukup
Scott R Collier
Appalachian State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledAntioxidants can decrease oxidative stress and combined with acute exercise they may lead to further decreases in blood pressure. The purpose of this study was to investigate the effects of 2 weeks of antioxidant supplementation on vascular distensibility and cardiovascular hemodynamics during postexercise hypotension.

methodsTwenty young subjects were randomized to placebo (n = 10) or antioxidant supplementation (n = 10) for two weeks. Antioxidant status, vascular distensibility, and hemodynamics were obtained before, immediately, and 30 minutes after an acute bout of aerobic exercise both before and after supplementation.

resultsTwo weeks of antioxidant supplementation resulted in a greater systolic blood pressure (SBP) decrease during postexercise hypotension (PEH) and significant decreases in augmentation index versus placebo (12.5% versus 3.5%, resp.). Also ferric-reducing ability of plasma (FRAP) increased significantly (interaction P = 0.024) after supplementation.

conclusionSupplementation showed an additive effect on PEH associated with increased FRAP values and decreases in systolic blood pressure and augmentation index.

Indexed as

Blood PressureDietary SupplementsAdolescentAdultFemaleFlavonoidsHemodynamicsHumansMaleOxidation-ReductionPost-Exercise HypotensionYoung AdultFlavonoids

Identifiers

PMID22191012
PMCPMC3236420
OpenAlexW2107178233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.