ArticleThe Journal of clinical and aesthetic dermatology2011
Nonsteroidal treatment of atopic dermatitis in pediatric patients with a ceramide-dominant topical emulsion formulated with an optimized ratio of physiological lipids.
Article in The Journal of clinical and aesthetic dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03089476 (Hypothesis), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypothesis: Skin Barrier Dysfunction With Altered Expression of Skin Barrier Proteins and Lipids Predicts Early Food Sensitizations in Infants at High Risk of Atopy
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Atopic Dermatitis: The Relationship Between Immune Mediators and Skin Lipid Barrier.Clinical reviews in allergy & immunology · 2025Review
- A review of the efficacy of popular eye cream ingredients.International journal of women's dermatology · 2024Review
- Efficacy of Topical Application of a Skin Moisturizer Containing Pseudo-Ceramide and a Eucalyptus Leaf Extract on Atopic Dermatitis: A Review.Journal of clinical medicine · 2024Review
- Mass-Spectrometry-Based Research of Cosmetic Ingredients.Molecules (Basel, Switzerland) · 2024Review
- The Role of a Novel Generation of Emollients, 'Emollients Plus', in Atopic Dermatitis.Clinical, cosmetic and investigational dermatology · 2022Review
- A Systematic Scoping Literature Review of Publications Supporting Treatment Guidelines for Pediatric Atopic Dermatitis in Contrast to Clinical Practice Patterns.Dermatology and therapy · 2018Article
- Atopic Dermatitis: Early Treatment in Children.Current treatment options in allergy · 2017Article
- Consensus Conference on Clinical Management of pediatric Atopic Dermatitis.Italian journal of pediatrics · 2016Review
- Atopic dermatitis: current treatment guidelines. Statement of the experts of the Dermatological Section, Polish Society of Allergology, and the Allergology Section, Polish Society of Dermatology.Postepy dermatologii i alergologii · 2015Article
- Epidermal permeability barrier defects and barrier repair therapy in atopic dermatitis.Allergy, asthma & immunology research · 2014Review
- Mass Spectrometry-based Lipidomics and Its Application to Biomedical Research.Journal of lifestyle medicine · 2014Review
- Shaping the landscape: metabolic regulation of S1P gradients.Biochimica et biophysica acta · 2013Review
- An update on the treatment of canine atopic dermatitis.Veterinary medicine (Auckland, N.Z.) · 2012Review
- Barrier-restoring therapies in atopic dermatitis: current approaches and future perspectives.Dermatology research and practice · 2012Article
- Management of patients with atopic dermatitis: the role of emollient therapy.Dermatology research and practice · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atopic dermatitis is the most common chronic inflammatory skin condition seen in the pediatric population. In the United States, the prevalence rate of atopic dermatitis is 10 to 12 percent in children. A nonsteroidal, barrier repair product consisting of an optimal ratio of ceramides, cholesterol, and free-fatty acids has been demonstrated to be efficacious and safe in the treatment of atopic dermatitis in previous clinical trials. This report is a subgroup analysis of the efficacy and safety of this nonsteroidal, ceramide-dominant, physiological lipid-based topical emulsion used among 59 patients, three months to 16 years of age, with mild-to-moderate atopic dermatitis. Treatment success based on an Investigator Global Assessment rating of clear or almost clear was achieved by 58 percent of subjects after use of the ceramide-dominant, physiological lipid barrier repair emulsion for three weeks as monotherapy or in combination with another topical atopic dermatitis treatment. The severity of pruritus decreased markedly from Baseline to Week 3 overall regardless of disease severity at baseline. A large percentage of subjects (71%) reported satisfaction with clinical results. After three weeks of treatment, a significant number of subjects reported less worry about their atopic dermatitis compared to baseline. The results further support other publications that suggest a treatment approach that incorporates an optimized formulation of a skin barrier repair cream as an integral component of initial atopic dermatitis therapy, either as monotherapy or as part of combination topical therapy.
Identifiers
22191005PMC3244356W1761900349What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.