ArticleInternational journal of dentistry2011
Susceptibility to dental caries and the salivary proline-rich proteins.
Article in International journal of dentistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 62 citations in OpenAlex.
- Acquired enamel pellicle and biofilm engineering with a combination of acid-resistant proteins (CaneCPI-5, StN15, and Hemoglobin) for enhanced protection against dental caries - in vivo and in vitro investigations.Clinical oral investigations · 2024Article
- Comparison between Serum and Salivary Albumin and Calcium Levels in Adolescent Age-group with Dental Caries.International journal of clinical pediatric dentistry · 2024Article
- Article
- Chemical Barrier Proteins in Human Body Fluids.Biomedicines · 2022Review
- Article
- Article
- Article
- Salivary Protein Roles in Oral Health and as Predictors of Caries Risk.Open life sciences · 2018Article
- Long-Term Dose-Response Condensed Tannin Supplementation Does Not Affect Iron Status or Bioavailability.Current developments in nutrition · 2017Article
- Advances in the microbial etiology and pathogenesis of early childhood caries.Molecular oral microbiology · 2017Review
- Salivary peptidome profiling analysis for occurrence of new carious lesions in patients with severe early childhood caries.PloS one · 2017Article
- Salivary peptidome profiling for diagnosis of severe early childhood caries.Journal of translational medicine · 2016Article
- Advances of Proteomic Sciences in Dentistry.International journal of molecular sciences · 2016Review
- A Study of the Variation in the Salivary Peptide Profiles of Young Healthy Adults Acquired Using MALDI-TOF MS.PloS one · 2016Observational
- Article
- Association of Salivary Statherin, Calcium, and Proline-Rich Proteins: A Potential Predictive Marker of Dental Caries.Contemporary clinical dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early childhood caries affects 28% of children aged 2-6 in the US and is not decreasing. There is a well-recognized need to identify susceptible children at birth. Caries-free adults neutralize bacterial acids in dental biofilms better than adults with severe caries. Saliva contains acidic and basic proline-rich proteins (PRPs) which attach to oral streptococci. The PRPs are encoded within a small region of chromosome 12. An acidic PRP allele (Db) protects Caucasian children from caries but is more common in African Americans. Some basic PRP allelic phenotypes have a three-fold greater frequency in caries-free adults than in those with severe caries. Early childhood caries may associate with an absence of certain basic PRP alleles which bind oral streptococci, neutralize biofilm acids, and are in linkage disequilibrium with Db in Caucasians. The encoding of basic PRP alleles is updated and a new technology for genotyping them is described.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.