ArticleInternational journal of dentistry2011
Analysis of polymorphisms in the lactotransferrin gene promoter and dental caries.
Article in International journal of dentistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis.BMC medical genetics · 2020Pooled it
- The association betweenHealth science reports · 2023Article
- The association between genetic polymorphisms in matrix metalloproteinases and caries experience.Clinical oral investigations · 2021Article
- Genetic Aspects of Dental Erosive Wear and Dental Caries.International journal of dentistry · 2021Review
- Lack of associations between lactoferrin (The Journal of international medical research · 2020Article
- Application of Antibiotics/Antimicrobial Agents on Dental Caries.BioMed research international · 2020Review
- Genes Involved in the Enamel Development Are Associated with Calcium and Phosphorus Level in Saliva.Caries research · 2017Article
- Early childhood caries is associated with genetic variants in enamel formation and immune response genes.Caries research · 2015Article
- Genetic Association of MPPED2 and ACTN2 with Dental Caries.Journal of dental research · 2014Article
- Caries: review of human genetics research.Caries research · 2014Review
- Role of TRAV locus in low caries experience.Human genetics · 2013Article
- Multi-dimensional prioritization of dental caries candidate genes and its enriched dense network modules.PloS one · 2013Article
- Fine-mapping of 5q12.1-13.3 unveils new genetic contributors to caries.Caries research · 2013Article
- Enamel formation genes influence enamel microhardness before and after cariogenic challenge.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regarding host aspects, there has been strong evidence for a genetic component in the etiology of caries. The salivary protein lactotransferrin (LTF) exhibits antibacterial activity, but there is no study investigating the association of polymorphisms in the promoter region of LTF gene with caries. The objective of this study was firstly to search the promoter region of the human LTF gene for variations and, if existent, to investigate the association of the identified polymorphisms with dental caries in 12-year-old students. From 687 unrelated, 12-year-old, both sex students, 50 individuals were selected and divided into two groups of extreme phenotypes according to caries experience: 25 students without (DMFT = 0) and 25 with caries experience (DMFT ≥ 4). The selection of individuals with extreme phenotypes augments the chances to find gene variations which could be associated with such phenotypes. LTF gene-putative promoter region (+39 to -1143) of the selected 50 individuals was analyzed by high-resolution melting technique. Fifteen students, 8 without (DMFT = 0) and 7 with caries experience (mean DMFT = 6.28), presented deviations of the pattern curve suggestive of gene variations and were sequenced. However, no polymorphisms were identified in the putative promoter region of the LTF gene.
Identifiers
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Registered trials
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