ArticleJournal of virology2012
Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Synergistic antiviral effects of structure-guided peptides and a mutagenic base analog on SARS-CoV-2 replication.Antimicrobial agents and chemotherapy · 2026Article
- Strategies and efforts in circumventing the emergence of antiviral resistance against conventional antivirals.npj antimicrobials and resistance · 2025Review
- Mutational landscapes of NITD008-resistant EV71 variants revealed through population sequencing.Virologica Sinica · 2025Article
- A tradeoff between enterovirus A71 particle stability and cell entry.Nature communications · 2023Article
- Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity.Viruses · 2022Review
- Cross-species transmission, evolution and zoonotic potential of coronaviruses.Frontiers in cellular and infection microbiology · 2022Review
- Increased RNA virus population diversity improves adaptability.Scientific reports · 2021Article
- An Extended Primer Grip of Picornavirus Polymerase Facilitates Sexual RNA Replication Mechanisms.Journal of virology · 2020Article
- A neonatal murine model of coxsackievirus A4 infection for evaluation of vaccines and antiviral drugs.Emerging microbes & infections · 2019Article
- Article
- Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.Journal of virology · 2017Article
- Attenuation of RNA viruses by redirecting their evolution in sequence space.Nature microbiology · 2017Article
- The Mutational Robustness of Influenza A Virus.PLoS pathogens · 2016Article
- Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Fidelity Variants and RNA Quasispecies.Current topics in microbiology and immunology · 2016Review
- Effective lethal mutagenesis of influenza virus by three nucleoside analogs.Journal of virology · 2015Article
- The study of homology between tumor progression genes and members of retroviridae as a tool to predict target-directed therapy failure.Frontiers in pharmacology · 2015Article
- Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases.Journal of virology · 2015Article
- Effect of mismatch repair on the mutation rate of bacteriophage ϕX174.Virus evolution · 2015Article
- Functional characterization of the mutations in Pepper mild mottle virus overcoming tomato tm-1-mediated resistance.Molecular plant pathology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational robustness relative to poliovirus, manifesting in enhanced sensitivity of CVB3 to lethal mutagens that is dependent on the size of the viral population. We suggest that mutational robustness may be a useful measure of the sensitivity of a virus to lethal mutagenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.