Evidence map›Paper›PMID 22190718›Full record

ArticleJournal of virology2012

Genome-scale phylogeny of the alphavirus genus suggests a marine origin.

N L Forrester, G Palacios, R B Tesh, N Savji, H Guzman, M Sherman, S C Weaver, W I Lipkin

Abstract read
In one paragraph

Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. iScience · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Current perspectives on alphavirus encapsidation, assembly and budding.Frontiers in cellular and infection microbiology · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

N L ForresterInstitute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA. naforres@utmb.edu
G Palacios
R B Tesh
N Savji
H Guzman
M Sherman
S C Weaver
W I Lipkin

Funding

Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LIPKIN, W. IAN · 2003 to 2014
$100.8M
Viral Arrays for BiodefenseU01AI070411 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2006 to 2010
$4.4M
Risk of Viral Emergence from BatsR01AI079231 · NIAID · ECOHEALTH ALLIANCE, INC. · PI DASZAK, PETER · 2008 to 2012
$2.6M
Mechanisms of sylvatic dengue emergenceR01AI069145 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2008 to 2011
$2.5M
NIAID NIH HHS AI069145NIAID NIH HHS AI070411NIAID NIH HHS AI079231NIAID NIH HHS AI57158NIAID NIH HHS R01 AI069145NIAID NIH HHS R01 AI079231NIAID NIH HHS U01 AI070411NIAID NIH HHS U54 AI057158PHS HHS HHSN27220100004OI/HHSN27200004/D04
6 · The paper itself

Abstract

The genus Alphavirus comprises a diverse group of viruses, including some that cause severe disease. Using full-length sequences of all known alphaviruses, we produced a robust and comprehensive phylogeny of the Alphavirus genus, presenting a more complete evolutionary history of these viruses compared to previous studies based on partial sequences. Our phylogeny suggests the origin of the alphaviruses occurred in the southern oceans and spread equally through the Old and New World. Since lice appear to be involved in aquatic alphavirus transmission, it is possible that we are missing a louse-borne branch of the alphaviruses. Complete genome sequencing of all members of the genus also revealed conserved residues forming the structural basis of the E1 and E2 protein dimers.

Indexed as

Evolution, MolecularGenome, ViralPhylogenyAlphavirusAlphavirus InfectionsAmino Acid SequenceAnimalsBirdsCattleFishesFur SealsHorsesHumansMolecular Sequence DataPrimatesRodentiaViral Proteins

Identifiers

PMID22190718
PMCPMC3302268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.