ArticleDevelopment (Cambridge, England)2012
Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- Soluble TREM1 Contributes to Aging-Related Neurodegeneration via ROBO2/ERK Pathway.Molecular neurobiology · 2026Article
- The Pro- But Not Antinociceptive Effects of Cannabidiol Depend on Trpa1b in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Identification of intestinal enteroendocrine cell subtypes and their associated hormones in zebrafish.PLoS biology · 2025Article
- Behavioral and circuit principles of temperature gradient navigation.Current biology : CB · 2025Article
- The pro-, but not anti-nociceptive effects of Cannabidiol depend on Trpa1b in larval Zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Molecular regulation of axon termination in mechanosensory neurons.Development (Cambridge, England) · 2024Review
- Single-Cell Analysis of Rohon-Beard Neurons Implicates Fgf Signaling in Axon Maintenance and Cell Survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A novel small molecule, AS1, reverses the negative hedonic valence of noxious stimuli.BMC biology · 2023Article
- Article
- Deficiency in the cell-adhesion moleculeFrontiers in cell and developmental biology · 2023Article
- The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns.Current neuropharmacology · 2022Article
- Osteoblasts pattern endothelium and somatosensory axons during zebrafish caudal fin organogenesis.Development (Cambridge, England) · 2022Article
- Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.Cell host & microbe · 2021Article
- Transparent Touch: Insights From Model Systems on Epidermal Control of Somatosensory Innervation.Frontiers in cellular neuroscience · 2021Review
- Current Methods to Investigate Nociception and Pain in Zebrafish.Frontiers in neuroscience · 2021Review
- Neurotrophins in the Brain of Teleost Fish: The State of the Art.Advances in experimental medicine and biology · 2021Review
- Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development.Disease models & mechanisms · 2020Article
- ZebrafishThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Hindbrain and Spinal Cord Contributions to the Cutaneous Sensory Innervation of the Larval Zebrafish Pectoral Fin.Frontiers in neuroanatomy · 2020Article
- Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.Translational psychiatry · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
How neurons connect to form functional circuits is central to the understanding of the development and function of the nervous system. In the somatosensory system, perception of sensory stimuli to the head requires specific connections between trigeminal sensory neurons and their many target areas in the central nervous system. Different trigeminal subtypes have specialized functions and downstream circuits, but it has remained unclear how subtype-specific axonal projection patterns are formed. Using zebrafish as a model system, we followed the development of two trigeminal sensory neuron subtypes: one that expresses trpa1b, a nociceptive channel important for sensing environmental chemicals; and a distinct subtype labeled by an islet1 reporter (Isl1SS). We found that Trpa1b and Isl1SS neurons have overall similar axon trajectories but different branching morphologies and distributions of presynaptic sites. Compared with Trpa1b neurons, Isl1SS neurons display reduced branch growth and synaptogenesis at the hindbrain-spinal cord junction. The subtype-specific morphogenesis of Isl1SS neurons depends on the guidance receptor Robo2. robo2 is preferentially expressed in the Isl1SS subset and inhibits branch growth and synaptogenesis. In the absence of Robo2, Isl1SS afferents acquire many of the characteristics of Trpa1b afferents. These results reveal that subtype-specific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.