ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Th1 and Th17 cells regulate innate immune responses and bacterial clearance during central nervous system infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- CD4+ T cell-innate immune crosstalk is critical during Staphylococcus aureus craniotomy infection.JCI insight · 2025Article
- Cellular Nanodiscs Made from Bacterial Outer Membrane as a Platform for Antibacterial Vaccination.ACS nano · 2022Article
- Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.PLoS pathogens · 2022Article
- Blood-Brain Barrier Alterations and Edema Formation in Different Brain Mass Lesions.Frontiers in cellular neuroscience · 2022Review
- Vaccine Composition Formulated with a NovelVaccines · 2021Article
- Hydroxychloroquine effects on miR-155-3p and miR-219 expression changes in animal model of multiple sclerosis.Metabolic brain disease · 2020Article
- Immunization with a Bacterial Lipoprotein Establishes an Immuno-Protective Response with Upregulation of Effector CD4+ T Cells and Neutrophils Against Methicillin-ResistantPathogens (Basel, Switzerland) · 2020Article
- Diabetic Stroke Promotes a Sexually Dimorphic Expansion of T Cells.Neuromolecular medicine · 2019Article
- Article
- Co-signaling receptors regulate T-cell plasticity and immune tolerance.Frontiers in bioscience (Landmark edition) · 2019Article
- VSIG-3 as a ligand of VISTA inhibits human T-cell function.Immunology · 2019Article
- Development of a novel S. Typhi and Paratyphi A outer membrane vesicles based bivalent vaccine against enteric fever.PloS one · 2018Article
- β1-Adrenergic Receptor Contains Multiple IAFrontiers in immunology · 2017Article
- Microglia-Mediated Inflammation and Neurodegenerative Disease.Molecular neurobiology · 2016Review
- Article
- CD4+ T cells promote the pathogenesis of Staphylococcus aureus pneumonia.The Journal of infectious diseases · 2015Article
- Article
- Ventricular shunt infections: immunopathogenesis and clinical management.Journal of neuroimmunology · 2014Review
- Th17 pathway-mediated immunopathogenesis of schizophrenia: mechanisms and implications.Schizophrenia bulletin · 2014Review
- T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Brain abscesses arise following parenchymal infection with pyogenic bacteria and are typified by inflammation and edema, which frequently results in a multitude of long-term health problems. The impact of adaptive immunity in shaping continued innate responses during late-stage brain abscess formation is not known but is important, because robust innate immunity is required for effective bacterial clearance. To address this issue, brain abscesses were induced in TCR αβ knockout (KO) mice, because CD4(+) and NKT cells represented the most numerous T cell infiltrates. TCR αβ KO mice exhibited impaired bacterial clearance during later stages of infection, which was associated with alterations in neutrophil and macrophage recruitment, as well as perturbations in cytokine/chemokine expression. Adoptive transfer of either Th1 or Th17 cells into TCR αβ KO mice restored bacterial burdens and innate immune cell infiltrates to levels detected in wild-type animals. Interestingly, adoptively transferred Th17 cells demonstrated plasticity within the CNS compartment and induced distinct cytokine secretion profiles in abscess-associated microglia and macrophages compared with Th1 transfer. Collectively, these studies identified an amplification loop for Th1 and Th17 cells in shaping established innate responses during CNS infection to maximize bacterial clearance and differentially regulate microglial and macrophage secretory profiles.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.