ArticleThe Journal of investigative dermatology2012
Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo.
Article in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 78 citations in OpenAlex.
- CD133 defines hair-inductive cells in the dermal papilla.Scientific reports · 2025Article
- CD133-positive dermal papilla cells are a major driver in promoting hair follicle formation.Research square · 2025Article
- Biofabrication of Human Skin with Its Appendages.Advanced healthcare materials · 2022Review
- Ficoll density gradient sedimentation isolation of pelage hair follicle mesenchymal stem cells from adult mouse back skin: a novel method for hair follicle mesenchymal stem cells isolation.Stem cell research & therapy · 2022Article
- Tissue engineering ECM-enriched controllable vascularized human microtissue for hair regenerative medicine using a biomimetic developmental approach.Journal of advanced research · 2022Article
- Detecting the Mechanism behind the Transition from Fixed Two-Dimensional Patterned Sika Deer (International journal of molecular sciences · 2021Article
- Differential Expression of Insulin-Like Growth Factor 1 and Wnt Family Member 4 Correlates With Functional Heterogeneity of Human Dermal Fibroblasts.Frontiers in cell and developmental biology · 2021Article
- Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Related Potentially to the Fineness of Cashmere Fiber.Frontiers in genetics · 2021Article
- Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold.Biomolecules · 2020Article
- Synchronous profiling and analysis of mRNAs and ncRNAs in the dermal papilla cells from cashmere goats.BMC genomics · 2019Article
- Use of human intra-tissue stem/progenitor cells and induced pluripotent stem cells for hair follicle regeneration.Inflammation and regeneration · 2019Review
- Skin Cell Heterogeneity in Development, Wound Healing, and Cancer.Trends in cell biology · 2018Review
- Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations.The Journal of investigative dermatology · 2018Article
- Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Fibroblast heterogeneity: implications for human disease.The Journal of clinical investigation · 2018Review
- Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid.Stem cells international · 2017Article
- Reply to Chi et al.The Journal of investigative dermatology · 2017Article
- CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth.The Biochemical journal · 2016Article
- Activating β-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity.The FEBS journal · 2016Article
- Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.Development (Cambridge, England) · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In neonatal mouse skin, two types of dermal papilla (DP) are distinguished by Sox2 expression: CD133+Sox2+ DP are associated with guard/awl/auchene hairs, whereas CD133+Sox2- DP are associated with zigzag (ZZ) hairs. We describe a three-dimensional hydrogel culture system that supports clonal growth of CD133+Sox2+, CD133+Sox2-, and CD133-Sox2- (non-DP) neonatal dermal cells. All three cell populations formed spheres that expressed the DP markers alkaline phosphatase, α8 integrin, and CD133. Nevertheless, spheres formed by CD133- cells did not efficiently support hair follicle formation in skin reconstitution assays. In the presence of freshly isolated P2 dermal cells, CD133+Sox2+ and CD133+Sox2- spheres contributed to the DP of both AA and ZZ hairs. Hair type did not correlate with sphere size. Sox2 expression was maintained in culture, but not induced significantly in Sox2- cells in vitro or in vivo, suggesting that Sox2+ cells are a distinct cellular lineage. Although Sox2+ cells were least efficient at forming spheres, they had the greatest ability to contribute to DP and non-DP dermis in reconstituted skin. As the culture system supports clonal growth of DP cells and maintenance of distinct DP cell types, it will be useful for further analysis of intrinsic and extrinsic signals controlling DP function.
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