ArticleClinics (Sao Paulo, Brazil)2011
Expression of TGF-β1 in the blood during fracture repair in an estrogen-deficient rat model.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Biomechanical Characteristics of Osteoporotic Fracture Healing in Ovariectomized Rats: A Systematic Review.PloS one · 2016Pooled it
- Two murine models of sepsis: immunopathological differences between the sexes-possible role of TGFβ1 in female resistance to endotoxemia.Biological research · 2023Article
- Analysis on risk factors for neck shortening after internal fixation for Pauwels II femoral neck fracture in young patients.European journal of medical research · 2021Article
- Exploring the Effect of Jiawei Buguzhi Pills on TGF-Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The function of microRNA-211 expression in post-fracture bone cell apoptosis involving the transforming growth factor-β/ phosphoinositide 3-kinase signaling pathway.The Journal of international medical research · 2020Article
- Identification of key genes influenced by fixation stability in early fracture hematoma and elucidation of their roles in fracture healing.Experimental and therapeutic medicine · 2017Article
- Effect of isopsoralen on Smad7 in osteoblastic MC3T3-E1 cells.Experimental and therapeutic medicine · 2017Article
- Transforming Growth Factor β1 (TGF-β1) in the Sera of Postmenopausal Osteoporotic Females.International journal of endocrinology and metabolism · 2016Article
- The Effects of Targeted Deliveries of Lovastatin and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model.International journal of environmental research and public health · 2015Article
- Associations of SAA1 gene polymorphism with lipid lelvels and osteoporosis in Chinese women.Lipids in health and disease · 2013Article
- Article
- Relationship between plasminogen activator inhibitor type-1 (PAI-1) gene polymorphisms and osteoporosis in Turkish women.Clinics (Sao Paulo, Brazil) · 2012Article
- Serum amyloid a gene polymorphism and its association with lipid profile in Saudi females with osteoporosis.Pakistan journal of medical sciencesArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPrevious studies have reported that osteoporosis due to estrogen deficiency influences fracture healing. Transforming growth factor (TGF-b) has been found to be involved in fracture healing via the regulation of the differentiation and activation of osteoblasts and osteoclasts. The current study aimed to determine the effects of estrogen on the expression of TGF-β1 during fracture healing in ovariectomized rats.
methodsThirty female Sprague-Dawley rats weighing 200-250 g were assigned to: (i) a sham-operated group that was given a normal saline; (ii) an ovariectomized control group that was given a normal saline; or (iii) an ovariectomized + estrogen (100 mg/kg/day) group that was treated with conjugated equine estrogen. The right femur of all rats was fractured, and a Kirschner wire was inserted six weeks post-ovariectomy. Treatment with estrogen was given for another six weeks post-fracture. At the end of the study, blood samples were taken, and the right femur was harvested and subjected to biomechanical strength testing.
resultsThe percentage change in the plasma TGF-β1 level before treatment was significantly lower in the ovariectomized control and estrogen groups when compared with the sham group (p<0.001). After six weeks of treatment, the percentage change in the plasma TGF-β1 level in the estrogen group was significantly higher compared with the level in the ovariectomized control group (p = 0.001). The mean ultimate force was significantly increased in the ovariectomized rats treated with estrogen when compared with the ovariectomized control group (p = 0.02).
conclusionThese data suggest that treatment with conjugated equine estrogen enhanced the strength of the healed bone in estrogen-deficient rats by most likely inducing the expression of TGF-β1.
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