ArticleClinics (Sao Paulo, Brazil)2011
Moderate exercise training promotes adaptations in coronary blood flow and adenosine production in normotensive rats.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Effects of physical exercise on the functionality of human nucleotidases: A systematic review.Physiological reports · 2022Pooled it
- Altered extracellular ATP, ADP, and AMP hydrolysis in blood serum of sedentary individuals after an acute, aerobic, moderate exercise session.Molecular and cellular biochemistry · 2017Trial
- The mechanism of exercise for pain management in Parkinson's disease.Frontiers in molecular neuroscience · 2022Review
- Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review.Purinergic signalling · 2021Review
- The Effect of Training on Erythrocyte Energy Status and Plasma Purine Metabolites in Athletes.Metabolites · 2019Article
- Physical exercise affects slow cycling cells in the rat heart and reveals a new potential niche area in the atrioventricular junction.Journal of molecular histology · 2015Article
- Cardioprotective effects of voluntary exercise in a rat model: role of matrix metalloproteinase-2.Oxidative medicine and cellular longevity · 2015Article
- The Rationale for Exercise in the Management of Pain in Parkinson's Disease.Journal of Parkinson's disease · 2015Review
- Article
- Interval and continuous exercise training produce similar increases in skeletal muscle and left ventricle microvascular density in rats.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAerobic exercise training prevents cardiovascular risks. Regular exercise promotes functional and structural adaptations that are associated with several cardiovascular benefits. The aim of this study is to investigate the effects of swimming training on coronary blood flow, adenosine production and cardiac capillaries in normotensive rats.
methodsWistar rats were randomly divided into two groups: control (C) and trained (T). An exercise protocol was performed for 10 weeks and 60 min/day with a tail overload of 5% bodyweight. Coronary blood flow was quantified with a color microsphere technique, and cardiac capillaries were quantified using light microscopy. Adenine nucleotide hydrolysis was evaluated by enzymatic activity, and protein expression was evaluated by western blot. The results are presented as the means ± SEMs (p<0.05).
resultsExercise training increased the coronary blood flow and the myocardial capillary-to-fiber ratio. Moreover, the circulating and cardiac extracellular adenine nucleotide hydrolysis was higher in the trained rats than in the sedentary rats due to the increased activity and protein expression of enzymes, such as E-NTPDase and 59'-nucleotidase.
conclusionsSwimming training increases coronary blood flow, number of cardiac capillaries, and adenine nucleotide hydrolysis. Increased adenosine production may be an important contributor to the enhanced coronary blood flow and angiogenesis that were observed in the exercise-trained rats; collectively, these results suggest improved myocardial perfusion.
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