ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2012
Prediction of fracture risk in men: a cohort study.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Pulsed electromagnetic field prevents lumbar bone loss in orchiectomy mice without altering systemic iron metabolism.Frontiers in bioengineering and biotechnology · 2025Article
- Birth weight and birth length affect future fracture risk differently in men and women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- The medication-based Rx-Risk Comorbidity Index and risk of hip fracture - a nationwide NOREPOS cohort study.BMC medicine · 2024Article
- Early menopause and weight loss are significant factors associated with risk of future fracture in middle-aged women.BMC musculoskeletal disorders · 2022Article
- Comparison of fracture risk calculators in elderly fallers: a hospital-based cross-sectional study.BMJ open · 2022Article
- Peri- and Interprosthetic Femoral Fractures-Current Concepts and New Developments for Internal Fixation.Journal of clinical medicine · 2022Review
- Association between statin use and osteoporotic fracture in patients with chronic obstructive pulmonary disease: a population-based, matched case-control study.Lipids in health and disease · 2020Article
- External validation and comparison of three prediction tools for risk of osteoporotic fractures using data from population based electronic health records: retrospective cohort study.BMJ (Clinical research ed.) · 2017Article
- Battle of the sex steroids in the male skeleton: and the winner is....The Journal of clinical investigation · 2016Article
- The impact of common co-morbidities (as measured using the Charlson index) on hip fracture risk in elderly men: a population-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- [Treatment of periprosthetic fractures : new concepts in operative treatment].Der Orthopade · 2014Article
- Comparison between various fracture risk assessment tools.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies.The American journal of clinical nutrition · 2014Observational
- Genetic influence on bone phenotypes and body composition: a Swedish twin study.Journal of bone and mineral metabolism · 2013Article
- Quantitative ultrasound measurements and vitamin D status in the assessment of hip fracture risk in a nationally representative population sample.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- [Treatment of periprosthetic and peri-implant fractures : modern plate osteosynthesis procedures].Der Unfallchirurg · 2012Review
- [Treatment of periprosthetic and peri-implant fractures : modern plate osteosynthesis procedures].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FRAX is a tool that identifies individuals with high fracture risk who will benefit from pharmacological treatment of osteoporosis. However, a majority of fractures among elderly occur in people without osteoporosis and most occur after a fall. Our aim was to accurately identify men with a high future risk of fracture, independent of cause. In the population-based Uppsala Longitudinal Study of Adult Men (ULSAM) and using survival analysis we studied different models' prognostic values (R(2)) for any fracture and hip fracture within 10 years from age 50 (n = 2322), 60 (n = 1852), 71 (n = 1221), and 82 (n = 526) years. During the total follow-up period from age 50 years, 897 fractures occurred in 585 individuals. Of these, 281 were hip fractures occurring in 189 individuals. The rates of any fracture were 5.7/1000 person-years at risk from age 50 years and 25.9/1000 person-years at risk from age 82 years. Corresponding hip fractures rates were 2.9 and 11.7/1000 person-years at risk. The FRAX model included all variables in FRAX except bone mineral density. The full model combining FRAX variables, comorbidity, medications, and behavioral factors explained 25% to 45% of all fractures and 80% to 92% of hip fractures, depending on age. The corresponding prognostic values of the FRAX model were 7% to 17% for all fractures and 41% to 60% for hip fractures. Net reclassification improvement (NRI) comparing the full model with the FRAX model ranged between 40% and 53% for any fracture and between 40% and 87% for hip fracture. Within the highest quintile of predicted fracture risk with the full model, one-third of the men will have a fracture within 10 years after age 71 years and two-thirds after age 82 years. We conclude that the addition of comorbidity, medication, and behavioral factors to the clinical components of FRAX can substantially improve the ability to identify men at high risk of fracture, especially hip fracture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.