ArticleHuman heredity2011
KELVIN: a software package for rigorous measurement of statistical evidence in human genetics.
Article in Human heredity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Meta-analysis of repository data: impact of data regularization on NIMH schizophrenia linkage results.PloS one · 2014Pooled it
- Gene × smoking interactions on human brain gene expression: finding common mechanisms in adolescents and adults.Journal of child psychology and psychiatry, and allied disciplines · 2013Pooled it
- Gene x environment interaction analysis confirms genetic modifier effects on steroid efficacy via TGF-β pathway in Duchenne muscular dystrophy.European journal of human genetics : EJHG · 2026Article
- Article
- A genome-wide association analysis of loss of ambulation in dystrophinopathy patients suggests multiple candidate modifiers of disease severity.European journal of human genetics : EJHG · 2023Article
- A fast linkage method for population GWAS cohorts with related individuals.Genetic epidemiology · 2023Article
- Common genetic risk factors in ASD and ADHD co-occurring families.Human genetics · 2023Article
- Article
- The PPLD has advantages over conventional regression methods in application to moderately sized genome-wide association studies.PloS one · 2021Article
- A new linear regression-like residual for survival analysis, with application to genome wide association studies of time-to-event data.PloS one · 2020Article
- A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees.Journal of neurodevelopmental disorders · 2018Article
- Validation of a microRNA target site polymorphism in H3F3B that is potentially associated with a broad schizophrenia phenotype.PloS one · 2018Article
- Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds.Behavior genetics · 2017Article
- A genome-wide linkage and association study of musical aptitude identifies loci containing genes related to inner ear development and neurocognitive functions.Molecular psychiatry · 2015Article
- Revisiting schizophrenia linkage data in the NIMH Repository: reanalysis of regularized data across multiple studies.The American journal of psychiatry · 2014Article
- The value of regenotyping older linkage data sets with denser marker panels.Human heredity · 2014Article
- A genome scan for loci shared by autism spectrum disorder and language impairment.The American journal of psychiatry · 2014Article
- Next-generation linkage and association methods applied to hypertension: a multifaceted approach to the analysis of sequence data.BMC proceedings · 2014Article
- A molecular genetic study of autism and related phenotypes in extended pedigrees.Journal of neurodevelopmental disorders · 2013Article
- Measurement of statistical evidence on an absolute scale following thermodynamic principles.Theory in biosciences = Theorie in den Biowissenschaften · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
This paper describes the software package KELVIN, which supports the PPL (posterior probability of linkage) framework for the measurement of statistical evidence in human (or more generally, diploid) genetic studies. In terms of scope, KELVIN supports two-point (trait-marker or marker-marker) and multipoint linkage analysis, based on either sex-averaged or sex-specific genetic maps, with an option to allow for imprinting; trait-marker linkage disequilibrium (LD), or association analysis, in case-control data, trio data, and/or multiplex family data, with options for joint linkage and trait-marker LD or conditional LD given linkage; dichotomous trait, quantitative trait and quantitative trait threshold models; and certain types of gene-gene interactions and covariate effects. Features and data (pedigree) structures can be freely mixed and matched within analyses. The statistical framework is specifically tailored to accumulate evidence in a mathematically rigorous way across multiple data sets or data subsets while allowing for multiple sources of heterogeneity, and KELVIN itself utilizes sophisticated software engineering to provide a powerful and robust platform for studying the genetics of complex disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.